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用琥珀酰胆碱解除痉挛,但要冒着因未诊断出的假性胆碱酯酶缺乏而导致术中知晓的风险。

Break the Spasm with Succinylcholine, but Risk Intraoperative Awareness with Undiagnosed Pseudocholinesterase Deficiency.

作者信息

Bui Danny D, Asher Shyamal R

机构信息

Rhode Island Hospital, Department of Anesthesiology, The Warren Alpert Medical School of Brown University, 593 Eddy St Davol 129, Providence, RI 02903, USA.

出版信息

Case Rep Anesthesiol. 2020 Sep 18;2020:8874617. doi: 10.1155/2020/8874617. eCollection 2020.

DOI:10.1155/2020/8874617
PMID:33014473
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7520683/
Abstract

Succinylcholine is a commonly used medication in all aspects of anesthetic care, and there are a number of known side effects and complications associated with its use. However, when succinylcholine is used emergently, anesthesia providers must remain vigilant to undiagnosed conditions that pose additional risks to patients. We report the use of succinylcholine to treat acute, refractory laryngospasm after extubation leading to prolonged neuromuscular paralysis. There are unique challenges presented by this case including the risk of anesthesia awareness with recall due to the cognitive biases that prevent the clinical diagnosis of pseudocholinesterase deficiency.

摘要

琥珀酰胆碱是麻醉护理各方面常用的药物,其使用存在一些已知的副作用和并发症。然而,当紧急使用琥珀酰胆碱时,麻醉医护人员必须对未诊断出的、给患者带来额外风险的情况保持警惕。我们报告了使用琥珀酰胆碱治疗拔管后急性难治性喉痉挛导致长时间神经肌肉麻痹的病例。该病例存在一些独特的挑战,包括由于认知偏差导致的麻醉知晓伴回忆风险,这些偏差会妨碍对假性胆碱酯酶缺乏症的临床诊断。

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本文引用的文献

1
Awareness during emergence from anesthesia: Features and future research directions.麻醉苏醒期的意识:特征与未来研究方向。
World J Clin Cases. 2020 Jan 26;8(2):245-254. doi: 10.12998/wjcc.v8.i2.245.
2
Butyrylcholinesterase deficiency and its clinical importance in anaesthesia: a systematic review.丁酰胆碱酯酶缺乏及其在麻醉中的临床意义:系统评价。
Anaesthesia. 2019 Apr;74(4):518-528. doi: 10.1111/anae.14545. Epub 2019 Jan 1.
3
Prolonged neuromuscular block associated with cholinesterase deficiency.与胆碱酯酶缺乏相关的长时间神经肌肉阻滞。
Medicine (Baltimore). 2018 Dec;97(52):e13714. doi: 10.1097/MD.0000000000013714.
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Pseudocholinesterase Deficiency: What the Proceduralist Needs to Know.假性胆碱酯酶缺乏症:术者须知。
Am J Med Sci. 2019 Mar;357(3):263-267. doi: 10.1016/j.amjms.2018.11.002. Epub 2018 Nov 10.
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A Case of Pseudocholinesterase Deficiency Resulting From Malnutrition.一例因营养不良导致的假性胆碱酯酶缺乏症
A A Case Rep. 2016 Sep 1;7(5):112-4. doi: 10.1213/XAA.0000000000000362.
6
Premature awakening and underuse of neuromuscular monitoring in a registry of patients with butyrylcholinesterase deficiency.在一项丁酰胆碱酯酶缺乏症患者登记研究中,存在过早觉醒和神经肌肉监测使用不足的情况。
Br J Anaesth. 2015 Jul;115 Suppl 1:i89-i94. doi: 10.1093/bja/aev103.
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Decision-making errors in anesthesiology.麻醉学中的决策错误。
Int Anesthesiol Clin. 2014 Winter;52(1):84-96. doi: 10.1097/AIA.0000000000000004.
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Cognitive processes in anesthesiology decision making.麻醉决策中的认知过程。
Anesthesiology. 2014 Jan;120(1):204-17. doi: 10.1097/ALN.0000000000000073.