Bjorgan Asgeir, Randeberg Lise Lyngsnes
Department of Electronic Systems, NTNU Norwegian University of Science and Technology, Trondheim, Norway.
Biomed Opt Express. 2020 Aug 17;11(9):5070-5091. doi: 10.1364/BOE.399636. eCollection 2020 Sep 1.
Detection of re-epithelialization in wound healing is important, but challenging. Hyperspectral imaging can be used for non-destructive characterization, but efficient techniques are needed to extract and interpret the information. An inverse photon transport model suitable for characterization of re-epithelialization is validated and explored in this study. It exploits scale-invariance to enable fitting of the epidermal skin layer only. Monte Carlo simulations indicate that the fitted layer transmittance and reflectance spectra are unique, and that there exists an infinite number of coupled parameter solutions. The method is used to explain the optical behavior of and detect re-epithelialization in an in vitro wound model.
检测伤口愈合过程中的再上皮化很重要，但具有挑战性。高光谱成像可用于无损表征，但需要有效的技术来提取和解释信息。本研究验证并探索了一种适用于表征再上皮化的逆光子传输模型。它利用尺度不变性仅对表皮层进行拟合。蒙特卡罗模拟表明，拟合的层透射率和反射率光谱是唯一的，并且存在无限数量的耦合参数解。该方法用于解释体外伤口模型中的光学行为并检测再上皮化。
