Espiridion Eduardo D, Valent Kyra, Qatanani Anas, Adesina Oluwakemi, Oladunjoye Adeolu O
Psychiatry, Drexel University College of Medicine, Philadelphia, USA.
Psychiatry, West Virginia School of Osteopathic Medicine, Lewisburg, USA.
Cureus. 2020 Aug 30;12(8):e10144. doi: 10.7759/cureus.10144.
Ganser syndrome (GS) is a rare neurological disorder characterized by answer approximation, clouded consciousness, somatic conversion symptoms, and visual or auditory hallucinations. The objective of this case report is to elucidate the presentation of a patient with GS and to highlight the interplay of psychological and organic determinants in this condition. We present a 66-year-old man with a history of concussion and short-term memory loss who presented with selective, remote, and recent memory loss following the death of his wife, visual hallucinations, approximation of answers regarding his current state, and limited insight into his condition. We found the patient oriented only to place and person, with impaired short-term memory and no language abnormalities. Montreal cognitive assessment (MOCA) exam showed mild-to-moderate cognitive impairment. The patient's presentation can be explained by both psychological and organic causes. Negative results from imaging and testing showed that the patient's recent emotional stressor, the death of his wife, may be contributing to the current state. However, the patient also has a history of hospitalization for traumatic brain injury (TBI) and a recent history of progressive memory loss. Therefore, the combination of psychological and organic factors likely played supplementary roles in the patient's current presentation. This case supports the literature that GS is a psychogenic disorder. However, an organic cause from the long-term sequelae of TBI needs further exploration.
甘塞尔综合征(GS)是一种罕见的神经系统疾病,其特征为近似回答、意识模糊、躯体转换症状以及视幻觉或听幻觉。本病例报告的目的是阐明一名甘塞尔综合征患者的临床表现,并强调心理和器质性因素在这种疾病中的相互作用。我们报告一名66岁男性,有脑震荡和短期记忆丧失病史,在其妻子去世后出现选择性、远期和近期记忆丧失、视幻觉、对自身当前状态的近似回答以及对自身病情的认识有限。我们发现该患者仅对地点和人物有定向力,短期记忆受损,且无语言异常。蒙特利尔认知评估(MOCA)测试显示轻度至中度认知障碍。患者的表现可由心理和器质性原因共同解释。影像学检查和测试结果均为阴性,表明患者近期的情绪应激源,即其妻子的去世,可能导致了目前的状态。然而,该患者既往有因创伤性脑损伤(TBI)住院的病史,且近期有进行性记忆丧失的病史。因此,心理和器质性因素的共同作用可能在患者目前的表现中起到了辅助作用。本病例支持了甘塞尔综合征是一种心因性疾病的文献观点。然而,创伤性脑损伤长期后遗症的器质性原因仍需进一步探究。