Bentaleb Ibtissam, Abdelghani Kawther Ben, Rostom Samira, Amine Bouchra, Laatar Ahmed, Bahiri Rachid
Service of Rheumatology A, El Ayachi Hospital, University Mohamed V Rabat, 11150 Salé, Morocco.
Faculty of Medicine, Mongi Slim Hospital, University of Tunis EL Manar, 2046 Tunis, Tunisia.
Curr Clin Microbiol Rep. 2020;7(4):124-132. doi: 10.1007/s40588-020-00152-6. Epub 2020 Sep 26.
The aim of this paper is to provide an overview about reactive arthritis, with an update regarding pathophysiology and therapeutic approach of the disease, outlining the clinical features and diagnostic approach, based on recent literature review.
Reactive arthritis is considered to be part of the spectrum of the spondyloarthritis. Its epidemiology is changing worldwide due to several reasons, among them are as follows: different diagnosis approach and clinical presentations, different grades of infection, microbiome changes, etc. The understanding of pathophysiological models is challenging, but recent studies contribute to elucidate the major factors involved in the development of the disease. The management of ReA depends on the triggering agent and the phase of disease, whether it is acute or chronic.
The association between the microbiome changes and spondyloarthropathies (ReA) is becoming increasingly evident. The results regarding the biologic treatment on refectory ReA are promising.
本文旨在对反应性关节炎进行概述，根据近期文献综述，更新该疾病的病理生理学和治疗方法，概述其临床特征和诊断方法。
反应性关节炎被认为是脊柱关节炎谱系的一部分。由于多种原因，其在全球的流行病学正在发生变化，其中包括：不同的诊断方法和临床表现、不同程度的感染、微生物群变化等。对病理生理模型的理解具有挑战性，但近期研究有助于阐明该疾病发展过程中的主要因素。反应性关节炎的治疗取决于触发因素和疾病阶段，无论是急性还是慢性阶段。
微生物群变化与脊柱关节病（反应性关节炎）之间的关联日益明显。关于难治性反应性关节炎生物治疗的结果很有前景。
