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[内毒素暴露对慢性胃瘘大白鼠胃液分泌的研究]

[Study of gastric secretion in white rats with a chronic gastric fistula on endotoxin exposure].

作者信息

Nikolov N, Zherev S

出版信息

Eksp Med Morfol. 1977;16(2):76-9.

PMID:330148
Abstract

The author carried out a study on the stomach secretion in white rats endotoxin shock, induced by venous adminsitration of endotoxin, obtained from Escherichia coli. Stomach fistula was made on the rats in advance and the stomach juice was collected under the condition of chronic experiment. The amount of stomach juice was estimated in mililiter per hour as well as the content of free hydrochloric acid, total aidity and electrophoresis of proteolytic enzymes. There was a statistically significnat lowering of the amount of stomach juice, diminuation of free hydrochloric acid and of total acidity acidity as well as diminution of complete disappearence of its proteolytic activity in the rats after endotoxin action.

摘要

作者对静脉注射从大肠杆菌获得的内毒素所致的大白鼠内毒素休克时的胃分泌进行了研究。预先给大鼠做胃瘘,在慢性实验条件下收集胃液。以每小时毫升数估算胃液量以及游离盐酸含量、总酸度和蛋白水解酶的电泳情况。内毒素作用后,大鼠的胃液量、游离盐酸和总酸度显著降低,其蛋白水解活性完全消失。

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