Zherev S, Nikolov N
Probl Khig. 1980;8:40-6.
The output of gastric secretion, gastric juice pH and its proteolytic activity are studied in twelve white rats in the state of endotoxic shock. Gastric juice from the animals is collected during two different periods - prior to shock, and during the shock - with the first period serving as a control. The proteolytic capacity of gastric juice is assayed enzymophoretically. In the course of endotoxin shock a statistically reliable decrease in gastric secretion output, as well as reduced acidity manifested with increase in pH and reduction to full disappearance of the proteolytic capacity of gastric juice are established in the animals experimented upon. The obtained results are interpreted in the light of direct and indirect inhibition of the gastric mucosa secretory activity.
对12只处于内毒素休克状态的白鼠的胃分泌量、胃液pH值及其蛋白水解活性进行了研究。在两个不同时期收集动物的胃液——休克前和休克期间,以第一个时期作为对照。采用酶电泳法测定胃液的蛋白水解能力。在内毒素休克过程中,实验动物的胃分泌量出现统计学上可靠的下降,同时pH值升高表明酸度降低,胃液的蛋白水解能力降低直至完全消失。根据对胃黏膜分泌活动的直接和间接抑制来解释所获得的结果。