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肾透明细胞癌肿瘤微环境中免疫相关细胞和基因的鉴定

Identification of Immune-Related Cells and Genes in Tumor Microenvironment of Clear Cell Renal Cell Carcinoma.

作者信息

Du Bowen, Zhou Yulin, Yi Xiaoming, Zhao Tangliang, Tang Chaopeng, Shen Tianyi, Zhou Kai, Wei Huixian, Xu Song, Dong Jie, Qu Le, He Haowei, Zhou Wenquan

机构信息

Department of Urology, Jinling Hospital, Medical School, Nanjing University, Nanjing, China.

出版信息

Front Oncol. 2020 Sep 2;10:1770. doi: 10.3389/fonc.2020.01770. eCollection 2020.

DOI:10.3389/fonc.2020.01770
PMID:33014871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7493752/
Abstract

Clear cell renal cell carcinoma (ccRCC) is one of the most common tumors in the urinary system. Progression in immunotherapy has provided novel options for the ccRCC treatment. However, the understanding of the ccRCC microenvironment and the potential therapeutic targets in the microenvironment is still unclear. Here, we analyzed the gene expression profile of ccRCC tumors from the Cancer Genome Atlas (TCGA) and calculated the abundance ratios of immune cells for each sample. Then, seven types of immune cells were found to be correlated to overall survival, and 3863 immune-related genes were identified by analyzing differentially expressed genes. We also found that the function of immune-related genes was mainly focused on ligand-receptor binding and signaling pathway transductions. Additionally, we identified 13 hub genes by analyzing the protein-protein interaction network, and seven of them are related to overall survival. Our study not only expands the understanding of fundamental biological features of microenvironment but also provides potential therapeutic targets.

摘要

透明细胞肾细胞癌（ccRCC）是泌尿系统中最常见的肿瘤之一。免疫治疗的进展为ccRCC的治疗提供了新的选择。然而，对ccRCC微环境及其微环境中潜在治疗靶点的了解仍不清楚。在此，我们分析了癌症基因组图谱（TCGA）中ccRCC肿瘤的基因表达谱，并计算了每个样本中免疫细胞的丰度比。然后，发现七种免疫细胞与总生存期相关，并通过分析差异表达基因鉴定出3863个免疫相关基因。我们还发现免疫相关基因的功能主要集中在配体-受体结合和信号通路转导上。此外，通过分析蛋白质-蛋白质相互作用网络，我们鉴定出13个枢纽基因，其中7个与总生存期相关。我们的研究不仅扩展了对微环境基本生物学特征的理解，还提供了潜在的治疗靶点。

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