Jiang Tao, Zhang Guangji, Lou Zhaohuan
School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Front Oncol. 2020 Sep 8;10:1788. doi: 10.3389/fonc.2020.01788. eCollection 2020.
Metabolic changes are a major feature of tumors, including various metabolic forms, such as energy, lipid, and amino acid metabolism. Sterol regulatory element binding proteins (SREBPs) are important modules in regulating lipid metabolism and play an essential role in metabolic diseases. In the previous decades, the regulatory range of SREBPs has been markedly expanded. It was found that SREBPs also played a critical role in tumor development. SREBPs are involved in energy supply, lipid supply, immune environment and inflammatory environment shaping in tumor cells, and as a protective umbrella to support the malignant proliferation of tumor cells. Natural medicine and traditional Chinese medicine, as an important part of drug therapy, demonstrates the multifaceted effects of SREBPs regulation. This review summarizes the core processes in the involvement of SREBPs in tumors and provides a comprehensive understanding of the pathways through which natural drugs target the SREBP pathway and regulate tumor progression.
代谢变化是肿瘤的主要特征，包括各种代谢形式，如能量、脂质和氨基酸代谢。固醇调节元件结合蛋白（SREBPs）是调节脂质代谢的重要模块，在代谢性疾病中起重要作用。在过去几十年中，SREBPs的调节范围显著扩大。研究发现，SREBPs在肿瘤发展中也起着关键作用。SREBPs参与肿瘤细胞的能量供应、脂质供应、免疫环境和炎症环境塑造，并作为支持肿瘤细胞恶性增殖的保护伞。天然药物和中药作为药物治疗的重要组成部分，展示了SREBPs调节的多方面作用。本综述总结了SREBPs参与肿瘤的核心过程，并全面了解天然药物靶向SREBP途径并调节肿瘤进展的途径。
