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葡萄牙新冠疫情的进展:基于非线性回归的活跃病例对比分析

On the Progression of COVID-19 in Portugal: A Comparative Analysis of Active Cases Using Non-linear Regression.

作者信息

Milhinhos Ana, Costa Pedro M

机构信息

Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.

Faculty of Sciences, BioISI - Biosystems & Integrative Sciences Institute, University of Lisboa, Lisbon, Portugal.

出版信息

Front Public Health. 2020 Sep 11;8:495. doi: 10.3389/fpubh.2020.00495. eCollection 2020.

Abstract

Portugal is often portrayed as a relatively successful case in the control of COVID-19's March 2020 outbreak in Europe due to timely confinement measures, commonly referred to as the "lockdown". As in other European Union member states, by late April, Portugal was preparing the phased loosening of such measures scheduled for the beginning of May. Despite a modest reduction in infection rates by that time, there was insufficient data to reliably forecast imminent scenarios. Using the South Korea data as scaffold, which became a paradigmatic case of recovery following a high number of infected people, we fitted the Portuguese data to biphasic models using non-linear regression and compared the two countries. The models, which yielded a good fit, showed that recovery would be slow, with over 50% active cases months after the lockdown. These findings acted at the time as a warning, showing that a high number of infected individuals, together with an unknown number of asymptomatic carriers, could increase the risk of a slow recovery, if not of new outbreaks. A month later, the models showed more favorable outcomes. However, shortly after, as the effects of leaving the lockdown became evident, the number of infections began rising again, leaving Portugal in a situation of inward and outward travel restrictions and baffling even the most conservative forecasts for the clearing of the pandemic.

摘要

葡萄牙常被视为在控制2020年3月欧洲新冠疫情爆发方面相对成功的案例,这得益于及时实施的限制措施,通常被称为“封锁”。与其他欧盟成员国一样,到4月底,葡萄牙正在准备分阶段放松原定于5月初实施的此类措施。尽管到那时感染率略有下降,但仍缺乏足够数据来可靠预测即将出现的情况。我们以韩国的数据为框架,韩国在大量感染病例后成为恢复的典型案例,我们使用非线性回归将葡萄牙的数据拟合到双相模型中,并对两国进行了比较。拟合效果良好的模型显示,恢复将很缓慢,封锁数月后仍有超过50%的活跃病例。这些发现当时起到了警示作用,表明大量感染者以及数量不明的无症状携带者,如果不引发新的疫情爆发,也可能增加恢复缓慢的风险。一个月后,模型显示出更有利的结果。然而,不久之后,随着解除封锁的影响显现,感染人数再次开始上升,使葡萄牙陷入国内外旅行限制的局面,甚至让对疫情清零最保守的预测也感到困惑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803f/7516009/beef02c8580e/fpubh-08-00495-g0001.jpg

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