Tang Hui, Cao Yi, Yang Xiang, Zhang Yuekang
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Department of Neurosurgery, Nanchong Central Hospital, The Second Clinical Medical College, North Sichuan Medical College, Nanchong, China.
Front Nutr. 2020 Sep 8;7:153. doi: 10.3389/fnut.2020.00153. eCollection 2020.
The present study was performed to systematically quantify the association between egg consumption and stroke risk as inconsistent results have been produced. Three electronic databases (PubMed, Embase, and Cochrane Library), previous reviews, meta-analyses, and bibliographies of relevant articles were retrieved from prospective cohort studies published before July 1, 2020. The random-effects model was employed to estimate summary relative risks (RRs) and 95% confidence intervals (CIs). A dose-response analysis was also performed when data were available. Sixteen publications involving 24 prospective cohort studies were included in our final meta-analysis. No significant association between egg consumption and stroke risk was identified (RR = 0.92, 95% CI: 0.84-1.01) for the highest vs. the lowest quintiles of egg intake. Subgroup analysis indicated that geographic location significantly modified the effect of egg consumption on stroke risk. Higher egg consumption was attributed to a reduced probability of stroke in Asia (RR = 0.83, 95% CI: 0.73-0.94), but not in North America (RR = 0.95, 95% CI: 0.77-1.16) or Europe (RR = 1.02, 95% CI: 0.91-1.16). Dose-response analysis demonstrated a nearly J-shaped curve between egg consumption and risk of stroke. A decreased risk was observed for the intake of one to four eggs weekly and an increased risk for the intake of more than six eggs weekly. The results were significant at an intake of 10 eggs weekly. The evidence from this meta-analysis showed that a J-shaped association exists between egg consumption and stroke risk.
由于此前关于鸡蛋摄入量与中风风险之间的研究结果并不一致，本研究旨在系统地量化二者之间的关联。我们从2020年7月1日前发表的前瞻性队列研究中检索了三个电子数据库（PubMed、Embase和Cochrane图书馆）、以往的综述、荟萃分析以及相关文章的参考文献。采用随机效应模型来估计汇总相对风险（RRs）和95%置信区间（CIs）。当有可用数据时，还进行了剂量反应分析。我们最终的荟萃分析纳入了16篇涉及24项前瞻性队列研究的文献。在鸡蛋摄入量最高与最低五分位数之间，未发现鸡蛋摄入量与中风风险之间存在显著关联（RR = 0.92，95% CI：0.84 - 1.01）。亚组分析表明，地理位置显著改变了鸡蛋摄入量对中风风险的影响。在亚洲，较高的鸡蛋摄入量与中风概率降低有关（RR = 0.83，95% CI：0.73 - 0.94），但在北美（RR = 0.95，95% CI：0.77 - 1.16）或欧洲（RR = 1.02，95% CI：0.91 - 1.16）并非如此。剂量反应分析表明，鸡蛋摄入量与中风风险之间呈现近似J形曲线。每周摄入1至4个鸡蛋时中风风险降低，而每周摄入超过6个鸡蛋时中风风险增加。每周摄入10个鸡蛋时结果具有显著性。这项荟萃分析的证据表明，鸡蛋摄入量与中风风险之间存在J形关联。
