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三阴性乳腺癌的表观遗传调控与饮食控制

Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer.

作者信息

Selmin Ornella I, Donovan Micah G, Stillwater Barbara J, Neumayer Leigh, Romagnolo Donato F

机构信息

Department of Nutritional Sciences, The University of Arizona, Tucson, AZ, United States.

University of Arizona Cancer Center, The University of Arizona, Tucson, AZ, United States.

出版信息

Front Nutr. 2020 Sep 8;7:159. doi: 10.3389/fnut.2020.00159. eCollection 2020.

DOI:10.3389/fnut.2020.00159
PMID:33015128
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7506147/
Abstract

Triple negative breast cancer (TNBC) represents a highly heterogeneous group of breast cancers, lacking expression of the estrogen (ER) and progesterone (PR) receptors, and human epidermal growth factor receptor 2 (HER2). TNBC are characterized by a high level of mutation and metastasis, poor clinical outcomes and overall survival. Here, we review the epigenetic mechanisms of regulation involved in cell pathways disrupted in TNBC, with particular emphasis on dietary food components that may be exploited for the development of effective strategies for management of TNBC.

摘要

三阴性乳腺癌（TNBC）是一组高度异质性的乳腺癌，缺乏雌激素（ER）和孕激素（PR）受体以及人表皮生长因子受体2（HER2）的表达。TNBC的特征是高水平的突变和转移、临床预后差以及总生存期短。在此，我们综述了TNBC中细胞通路紊乱所涉及的表观遗传调控机制，特别强调了可能用于开发TNBC有效管理策略的膳食成分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2258/7506147/88de4a6b8c51/fnut-07-00159-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2258/7506147/0f8c80ef69db/fnut-07-00159-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2258/7506147/18edaa2d1a91/fnut-07-00159-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2258/7506147/88de4a6b8c51/fnut-07-00159-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2258/7506147/0f8c80ef69db/fnut-07-00159-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2258/7506147/18edaa2d1a91/fnut-07-00159-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2258/7506147/88de4a6b8c51/fnut-07-00159-g0003.jpg

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