钙化性主动脉瓣狭窄患者中自分泌运动因子与脂蛋白(a)的相互作用。

Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis.

作者信息

Bourgeois Raphaëlle, Devillers Romain, Perrot Nicolas, Després Audrey-Anne, Boulanger Marie-Chloé, Mitchell Patricia L, Guertin Jakie, Couture Patrick, Boffa Michael B, Scipione Corey A, Pibarot Philippe, Koschinsky Marlys L, Mathieu Patrick, Arsenault Benoit J

机构信息

Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada.

Department of Medicine, Faculty of Medicine, Université Laval, Québec, Canada.

出版信息

JACC Basic Transl Sci. 2020 Aug 26;5(9):888-897. doi: 10.1016/j.jacbts.2020.06.012. eCollection 2020 Sep.

Our objectives were to determine whether autotaxin (ATX) is transported by lipoprotein(a) [Lp(a)] in human plasma and if could be used as a biomarker of calcific aortic valve stenosis (CAVS). We first found that ATX activity was higher in Lp(a) compared to low-density lipoprotein fractions in isolated fractions of 10 healthy participants. We developed a specific assay to measure ATX-Lp(a) in 88 patients with CAVS and 144 controls without CAVS. In a multivariable model corrected for CAVS risk factors, ATX-Lp(a) was associated with CAVS (p = 0.003). We concluded that ATX is preferentially transported by Lp(a) and might represent a novel biomarker for CAVS.