Surendran Arun, Edel Andrea, Chandran Mahesh, Bogaert Pascal, Hassan-Tash Pedram, Kumar Asokan Aneesh, Hiebert Brett, Solati Zahra, Sandhawalia Shubhkarman, Raabe Michael, Kass Malek, Shah Ashish, Jassal Davinder S, Jaleel Abdul, Ravandi Amir
Cardiovascular Lipidomics Laboratory, St. Boniface Hospital, Albrechtsen Research Centre, Winnipeg, Manitoba, Canada.
Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
JACC Basic Transl Sci. 2020 Dec 16;5(12):1163-1177. doi: 10.1016/j.jacbts.2020.10.001. eCollection 2020 Dec.
This study outlines the first step toward creating the metabolite atlas of human calcified aortic valves by identifying the expression of metabolites and metabolic pathways involved at various stages of calcific aortic valve stenosis progression. Untargeted analysis identified 72 metabolites and lipids that were significantly altered (p < 0.01) across different stages of disease progression. Of these metabolites and lipids, the levels of lysophosphatidic acid were shown to correlate with faster hemodynamic progression and could select patients at risk for faster progression rate.
本研究通过鉴定钙化性主动脉瓣狭窄进展各阶段所涉及的代谢物表达和代谢途径，概述了创建人类钙化主动脉瓣代谢物图谱的第一步。非靶向分析鉴定出72种在疾病进展不同阶段有显著变化（p < 0.01）的代谢物和脂质。在这些代谢物和脂质中，溶血磷脂酸水平与更快的血流动力学进展相关，并且可以筛选出进展速度较快的高危患者。
