Lin Jiajia, Nguyen Nhu-Y Thi, Zhang Chaoxing, Ha Alexandra, Liu Huinan Hannah
Material Science & Engineering Program, University of California, Riverside, 900 University Avenue, Riverside, California 92521, United States.
Microbiology Program, University of California, Riverside, 900 University Avenue, Riverside, California 92521, United States.
ACS Omega. 2020 Sep 18;5(38):24613-24627. doi: 10.1021/acsomega.0c03151. eCollection 2020 Sep 29.
Magnesium (Mg) and its alloys have attracted increasing attention in recent years as medical implants for repairing musculoskeletal injuries because of their promising mechanical and biological properties. However, rapid degradation of Mg and its alloys in physiological fluids limited their clinical translation because the accumulation of hydrogen (H) gas and fast release of OH ions could adversely affect the healing process. Moreover, infection is a major concern for internally implanted devices because it could lead to biofilm formation, prevent host cell attachment on the implants, and interfere osseointegration, resulting in implant failure or other complications. Fabricating nanostructured magnesium oxide (MgO) on magnesium (Mg) substrates is promising in addressing both problems because it could slow down the degradation process and improve the antimicrobial activity. In this study, nanostructured MgO layers were created on Mg substrates using two different surface treatment techniques, i.e., anodization and electrophoretic deposition (EPD), and cultured with in vitro to determine their antimicrobial properties. At the end of the 24-h bacterial culture, the nanostructured MgO layers on Mg prepared by anodization or EPD both showed significant bactericidal effect against . Thus, nanostructured MgO layers on Mg are promising for reducing implant-related infections and complications and should be further explored for clinical translation toward antimicrobial biodegradable implants.
近年来，镁（Mg）及其合金作为修复肌肉骨骼损伤的医用植入物受到了越来越多的关注，因为它们具有良好的机械性能和生物学性能。然而，镁及其合金在生理流体中的快速降解限制了它们的临床应用，因为氢气（H）的积累和氢氧根离子的快速释放会对愈合过程产生不利影响。此外，感染是体内植入装置的一个主要问题，因为它可能导致生物膜形成，阻止宿主细胞附着在植入物上，并干扰骨整合，从而导致植入失败或其他并发症。在镁（Mg）基底上制备纳米结构的氧化镁（MgO）有望解决这两个问题，因为它可以减缓降解过程并提高抗菌活性。在本研究中，使用两种不同的表面处理技术，即阳极氧化和电泳沉积（EPD），在镁基底上制备了纳米结构的MgO层，并在体外进行培养以确定其抗菌性能。在24小时细菌培养结束时，通过阳极氧化或EPD制备的镁上的纳米结构MgO层对[具体细菌名称未给出]均显示出显著的杀菌效果。因此，镁上的纳米结构MgO层有望减少与植入物相关的感染和并发症，应进一步探索其向抗菌可生物降解植入物的临床转化。
