Department of Emergency Medicine, Santi Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy.
Eur Rev Med Pharmacol Sci. 2020 Sep;24(18):9695-9697. doi: 10.26355/eurrev_202009_23060.
Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a newly emergent coronavirus, SARS-CoV-2. The acute phase may be followed by a second phase actually not yet completely understood but probably associated to an autoimmune activation. At the moment is not possible to clearly define an association between immunological findings and pathological symptoms, however, this case report describes the case of a patient who following COVID-19 infection development autoimmune antibodies who persist in time longer than viral phase. Those antibodies can be responsible for the multi pathological clinical picture showed from our patient that, according to EULAR 2019 criteria, could be classified as systemic lupus erythematosus (SLE). SLE is probably one of the possible chronic rheumatologic diseases triggers by COVID-19 and this is the first case of SLE with vasculitis actually described in literature.
2019 年冠状病毒病（COVID-19）是一种由新型冠状病毒 SARS-CoV-2 引起的呼吸道感染。急性期后可能会出现第二阶段，目前尚不完全清楚，但可能与自身免疫激活有关。目前尚无法明确将免疫发现与病理症状联系起来，但本病例报告描述了一例 COVID-19 感染后自身免疫抗体持续存在的患者。这些抗体可能是导致我们的患者表现出多系统病理临床症状的原因，根据 EULAR 2019 标准，这些症状可归类为系统性红斑狼疮（SLE）。SLE 可能是 COVID-19 引发的慢性风湿性疾病之一，而这是文献中首次描述的伴有血管炎的 SLE 病例。
