印度尼西亚日惹地区经肾活检诊断的肾脏疾病模式及2019冠状病毒病大流行的影响：一项单中心研究

Patterns of kidney diseases diagnosed by kidney biopsy and the impact of the COVID-19 pandemic in Yogyakarta, Indonesia: A single-center study.

作者信息

Puspitasari Metalia, Wardhani Yulia, Sattwika Prenali Dwisthi, Wijaya Wynne

机构信息

Department of Internal Medicine, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.

Clinical Epidemiology and Biostatistics Unit, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.

出版信息

World J Nephrol. 2024 Dec 25;13(4):100087. doi: 10.5527/wjn.v13.i4.100087.

DOI:10.5527/wjn.v13.i4.100087

PMID:39723352

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11572650/

Abstract

BACKGROUND

Glomerular diseases rank third among the causes of chronic kidney disease worldwide and in Indonesia, and its burden continues to increase, especially regarding the sociodemographic index. Kidney biopsy remains the gold standard for the diagnosis and classification of glomerular diseases. It is crucial for developing treatment plans, determining the degree of histologic changes, and identifying disease relapse.

AIM

To describe the patterns of biopsy-proven kidney diseases in adult patients.

METHODS

We retrospectively reviewed the demographic, histopathologic, clinical, and laboratory data of 75 adult patients with biopsy-proven kidney diseases at our institution recorded from 2017 to 2022.

RESULTS

Among the patients, 43 (57.3%) were females, and the mean age was 31.52 years ± 11.70 years. The most common histopathologies were lupus nephritis (LN) (33.3%), minimal change disease (MCD) (26.7%), and focal segmental glomerulosclerosis (10.7%). LN (41.7%) was frequently diagnosed in women and MCD (28.1%) in men. The most common cause of nephritic syndrome was LN (36.7%) and of nephrotic syndrome was MCD (40%).

CONCLUSION

Different kidney disease patterns were observed in different sexes, age categories, clinical syndromes, and biopsy dates relative to the coronavirus disease 2019 pandemic.

摘要

背景

在全球和印度尼西亚，肾小球疾病是慢性肾脏病的第三大病因，其负担持续增加，尤其是在社会人口统计学指数方面。肾活检仍然是肾小球疾病诊断和分类的金标准。对于制定治疗方案、确定组织学改变程度以及识别疾病复发至关重要。

目的

描述经活检证实的成年患者肾脏疾病模式。

方法

我们回顾性分析了2017年至2022年在我院记录的75例经活检证实患有肾脏疾病的成年患者的人口统计学、组织病理学、临床和实验室数据。

结果

患者中，43例（57.3%）为女性，平均年龄为31.52岁±11.70岁。最常见的组织病理学类型为狼疮性肾炎（LN）（33.3%）、微小病变病（MCD）（26.7%）和局灶节段性肾小球硬化（10.7%）。LN（41.7%）在女性中更常被诊断出，而MCD（28.1%）在男性中更常被诊断出。肾炎综合征最常见的病因是LN（36.7%），肾病综合征最常见的病因是MCD（40%）。