Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Eur Rev Med Pharmacol Sci. 2020 Sep;24(18):9744-9747. doi: 10.26355/eurrev_202009_23067.
ACE2 long served as the human gateway for multiple coronaviruses, including the currently pandemic SARS-CoV-2. This mini-review explores the potential of targeting ACE2 in blocking viral penetrance.
PubMed search was conducted using the terms: "coronaviridae", "peptidyl-dipeptidase A", "ACE2", "SARS", and "SARS-CoV-2". References of relevant articles were further screened by the author.
Four main methods of blocking ACE2-mediated viral penetrance were identified: receptor blockage, receptor decoying, receptor shedding, and co-receptor inhibition.
Drugs that inhibit viral binding to ACE2 present a strong choice for the current, and if necessary, future outbreaks. Further research is needed to establish the clinical and pharmacological aspects of the identified candidate molecules.
ACE2 长期以来一直是多种冠状病毒（包括目前流行的 SARS-CoV-2）进入人体的门户。本综述探讨了靶向 ACE2 以阻止病毒侵袭的可能性。
使用以下术语在 PubMed 上进行检索：“冠状病毒科”、“肽二肽酶 A”、“ACE2”、“SARS”和“SARS-CoV-2”。作者进一步筛选了相关文章的参考文献。
确定了四种阻断 ACE2 介导的病毒侵袭的主要方法：受体阻断、受体诱饵、受体脱落和共受体抑制。
抑制病毒与 ACE2 结合的药物是目前（如果必要，还包括未来）爆发的有力选择。需要进一步研究以确定已确定候选分子的临床和药理学方面。
