Section of Nephrology, Department of Pediatrics, Wake Forest School of Medicine and Brenner Children's Hospital, Winston Salem, NC, USA.
Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC, USA.
Nat Rev Nephrol. 2020 Jun;16(6):305-307. doi: 10.1038/s41581-020-0279-4.
The current COVID-19 pandemic is associated with unprecedented morbidity and mortality. Early reports suggested an association between disease severity and hypertension but did not account for sources of confounding. However, the responsible virus — SARS-CoV-2 — gains entry to host cells via angiotensin-converting enzyme 2 (ACE2), highlighting the need to understand the relationship between the virus and the renin–angiotensin system (RAS) and how this might be affected by RAS inhibitors.
当前的 COVID-19 大流行与前所未有的发病率和死亡率有关。早期报告表明疾病严重程度与高血压之间存在关联，但并未考虑混杂因素的来源。然而，致病病毒——SARS-CoV-2 通过血管紧张素转换酶 2（ACE2）进入宿主细胞，这凸显了理解病毒与肾素-血管紧张素系统（RAS）之间的关系以及 RAS 抑制剂如何受到影响的必要性。
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