Department of Infection and Immunology, Aichi Children's Health and Medical Center, Obu, Aichi, Japan.
Department of Dermatology, Aichi Children's Health and Medical Center, Obu, Aichi, Japan.
Mod Rheumatol Case Rep. 2021 Jan;5(1):137-140. doi: 10.1080/24725625.2020.1749359. Epub 2020 Oct 5.
An 8-year-old girl was presented to our clinic with fever, arthritis in her left knee, a necrotic right fifth toe, and multiple large deep-seated ulcerations. She was diagnosed with pyoderma gangrenosum. Treatment with corticosteroids alone was ineffective for her skin lesions, and therefore combination immunosuppressant therapy was administered. Her skin lesions rapidly improved, enabling discontinuation of the corticosteroid therapy and avoiding systemic infection through the ulcers. Combination immunosuppressant therapy may be a treatment option for patients with severe, rapidly progressive pyoderma gangrenosum.
一位 8 岁女孩因发热、左膝关节炎、右侧第五脚趾坏死以及多处大而深的溃疡而到我院就诊。她被诊断为坏疽性脓皮病。单独使用皮质类固醇治疗对其皮肤病变无效，因此给予联合免疫抑制剂治疗。她的皮肤病变迅速改善，使皮质类固醇治疗得以停止，并避免了溃疡引起的全身感染。对于严重、快速进展性坏疽性脓皮病患者，联合免疫抑制剂治疗可能是一种治疗选择。
