Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo, 060-0812, Japan.
Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo, 060-0812, Japan.
Chem Asian J. 2020 Nov 16;15(22):3771-3783. doi: 10.1002/asia.202001034. Epub 2020 Oct 23.
Iridoids are a large family of monoterpenoids found in traditional medicinal plants and show significant effects for the human species. In addition to their wide range of biological activities, such as neuroprotective and antitumor activities, the cis-fused bicyclic ring systems of iridoids are still attractive as synthetic targets to apply novel synthetic methodologies. Accordingly, recent progress regarding the biosynthesis and chemical synthesis of iridoids is covered in this minireview. Identification of new enzymes for the iridoid biosynthesis in Catharanthus roseus and ingenious synthetic strategies for the construction of the iridoid skeleton are described.
环烯醚萜类是在传统药用植物中发现的一大类单萜类化合物，对人类具有显著的作用。除了具有广泛的生物活性，如神经保护和抗肿瘤活性外，环烯醚萜类的顺式稠合双环体系仍然是具有吸引力的合成目标，可应用新的合成方法。因此，本综述涵盖了环烯醚萜类的生物合成和化学合成的最新进展。描述了长春花中新的环烯醚萜类生物合成酶的鉴定和构建环烯醚萜骨架的巧妙合成策略。
