Safar M E, London G M
Hypertension. 1987 Aug;10(2):133-9. doi: 10.1161/01.hyp.10.2.133.
Arterial and venous compliances are decreased in men with sustained essential hypertension. The reduced arterial compliance acts to maintain systolic pressure and end-systolic stress, thus contributing to the development of cardiac hypertrophy. Since cardiac output remains within the normal range in the hypertrophied hypertensive heart, elevated left ventricular pressures, and therefore increased cardiac filling pressures, are necessary if an adequate stroke volume is to be maintained. In hypertensive persons, reduced venous compliance acts to maintain the filling pressure of the heart in the presence of reduced intravascular volume. In patients with hypertension, even if compliance changes have been initiated by the elevated blood pressure itself, the reduced arterial and venous compliance observed in cross-sectional studies is not simply the mechanical consequence of the elevated blood pressure, but also reflects intrinsic alterations of the vascular wall. Consequently, blood pressure reduction caused by antihypertensive agents is not constantly associated with a reversion of the decreased vascular compliance. Such observations may be of importance in the consideration of cardiovascular morbidity and mortality in patients treated for hypertension.
持续性原发性高血压男性的动脉和静脉顺应性降低。动脉顺应性降低会维持收缩压和收缩末期应力，从而导致心脏肥大。由于在肥厚性高血压心脏中的心输出量仍在正常范围内，因此，如果要维持足够的每搏输出量，升高的左心室压力以及因此增加的心脏充盈压是必要的。在高血压患者中，静脉顺应性降低会在血管内容量减少的情况下维持心脏的充盈压。在高血压患者中，即使顺应性变化是由血压本身升高引起的，横断面研究中观察到的动脉和静脉顺应性降低不仅是血压升高的机械结果，还反映了血管壁的内在改变。因此，降压药引起的血压降低并不总是与血管顺应性降低的逆转相关。这些观察结果对于考虑高血压治疗患者的心血管发病率和死亡率可能很重要。
