迈向心脏异种移植的进展。
Progress Toward Cardiac Xenotransplantation.
机构信息
Division of Cardiac Surgery, Department of Surgery (R.N.P., D.A.D., M.R.C., L.B., J.C.M., A.M.A.), Massachusetts General Hospital and Harvard University, Boston.
Center for Transplantation Sciences (R.N.P., J.A.F., M.R.C., L.B., J.C.M., A.M.A.), Massachusetts General Hospital and Harvard University, Boston.
出版信息
Circulation. 2020 Oct 6;142(14):1389-1398. doi: 10.1161/CIRCULATIONAHA.120.048186. Epub 2020 Oct 5.
Abstract
Consistent survival of life-supporting pig heart xenograft recipients beyond 90 days was recently reported using genetically modified pigs and a clinically applicable drug treatment regimen. If this remarkable achievement proves reproducible, published benchmarks for clinical translation of cardiac xenografts appear to be within reach. Key mechanistic insights are summarized here that informed recent pig design and therapeutic choices, which together appear likely to enable early clinical translation.
摘要
最近有报道称，使用经过基因改造的猪和一种临床适用的药物治疗方案，可使接受猪心异种移植的患者的生命支持时间超过 90 天。如果这一显著成就能够重现，那么心脏异种移植临床转化的现有基准似乎触手可及。本文总结了一些关键的机制见解，这些见解为最近的猪设计和治疗选择提供了信息，这些选择似乎有可能使异种移植能够早日进入临床。
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本文引用的文献
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Am J Transplant. 2020 Oct;20(10):2669-2674. doi: 10.1111/ajt.15916. Epub 2020 May 25.
2
A Comprehensive Strategy for Screening for Xenotransplantation-Relevant Viruses in a Second Isolated Population of Göttingen Minipigs.在第二群隔离饲养的哥廷根小型猪中筛查异种移植相关病毒的综合策略
Viruses. 2019 Dec 29;12(1):38. doi: 10.3390/v12010038.
3
Viable pigs after simultaneous inactivation of porcine MHC class I and three xenoreactive antigen genes GGTA1, CMAH and B4GALNT2.同时灭活猪 MHC Ⅰ类基因和三个异种反应性抗原基因 GGTA1、CMAH 和 B4GALNT2 后的存活猪。
Xenotransplantation. 2020 Jan;27(1):e12560. doi: 10.1111/xen.12560. Epub 2019 Oct 8.
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J Thorac Cardiovasc Surg. 2020 Jan;159(1):166-169. doi: 10.1016/j.jtcvs.2019.04.087. Epub 2019 Jun 14.
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Consistent success in life-supporting porcine cardiac xenotransplantation.在支持猪心异种移植方面取得持续成功。
Nature. 2018 Dec;564(7736):430-433. doi: 10.1038/s41586-018-0765-z. Epub 2018 Dec 5.
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