全基因组测序揭示了单形性上皮样肠道T细胞淋巴瘤的有效治疗策略。
Whole-genome sequencing reveals potent therapeutic strategy for monomorphic epitheliotropic intestinal T-cell lymphoma.
作者信息
Huang Dachuan, Lim Jing Quan, Cheah Daryl Ming Zhe, Kahliab Khalilatul Hanisah Binte Mohd, Laurensia Yurike, Pang Jane Wan Lu, Wong Esther Kam Yin, Chia Burton Kuan Hui, Goh Jasmine, Zhang Xiyun, Chan Jason Yongsheng, Chow Edward Kai-Hua, Tan Soo Yong, Lim Soon Thye, Ong Choon Kiat
机构信息
Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, National Cancer Centre, Singapore.
Duke-NUS Medical School, Singapore.
出版信息
Blood Adv. 2020 Oct 13;4(19):4769-4774. doi: 10.1182/bloodadvances.2020001782.
Abstract
Whole genomic and transcriptomic analyses of MEITL revealed multiple potential therapeutic targets. Synergistic effects of pimozide and romidepsin are shown in a well-characterized MEITL PDX model.
摘要
对肠病相关T细胞淋巴瘤（MEITL）的全基因组和转录组分析揭示了多个潜在治疗靶点。在一个特征明确的MEITL人源肿瘤异种移植（PDX）模型中显示了匹莫齐特和罗米地辛的协同作用。
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