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Whole-genome sequencing reveals potent therapeutic strategy for monomorphic epitheliotropic intestinal T-cell lymphoma.全基因组测序揭示了单形性上皮样肠道T细胞淋巴瘤的有效治疗策略。
Blood Adv. 2020 Oct 13;4(19):4769-4774. doi: 10.1182/bloodadvances.2020001782.
2
Monomorphic Epitheliotropic Intestinal T-cell Lymphoma: A Study of Four Cases and Review of Literature.单一表型上皮样肠道 T 细胞淋巴瘤：四例病例研究及文献复习。
Ann Clin Lab Sci. 2020 Nov;50(6):806-812.
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Monomorphic epitheliotropic intestinal T-cell lymphoma may mimic intestinal inflammatory disorders.单一表型上皮嗜肠 T 细胞淋巴瘤可能类似于肠道炎症性疾病。
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Monomorphic epitheliotropic intestinal T-cell lymphoma in pleural effusion: A case report.胸腔积液中出现的单形性嗜上皮性肠道T细胞淋巴瘤：一例报告
Diagn Cytopathol. 2017 Nov;45(11):1050-1054. doi: 10.1002/dc.23772. Epub 2017 Jul 5.
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Positron emission tomography computed tomography features of monomorphic epitheliotropic intestinal T-cell lymphoma.单形性亲上皮性肠道T细胞淋巴瘤的正电子发射断层扫描计算机断层扫描特征
Hematology. 2018 Jan;23(1):10-16. doi: 10.1080/10245332.2017.1335979. Epub 2017 Jun 5.
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Monomorphic Epitheliotropic Intestinal T-cell Lymphoma of the Stomach: Two Case Reports and a Literature Review.胃单形上皮样肠道 T 细胞淋巴瘤：两例报告及文献复习。
Int J Surg Pathol. 2021 Jun;29(4):410-419. doi: 10.1177/1066896920953906. Epub 2020 Aug 28.
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Monomorphic epitheliotropic intestinal T cell lymphoma presenting in weblike feature.以网状特征呈现的单形性上皮嗜性肠道T细胞淋巴瘤。
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[The clinical characteristics of patients with monomorphic epitheliotropic intestinal T-cell lymphoma characterized by minor endoscopic abnormalities].[以轻微内镜异常为特征的单形性嗜上皮性肠道T细胞淋巴瘤患者的临床特征]
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Gastrointestinal: Endoscopic findings of monomorphic epitheliotropic intestinal T-cell lymphoma.胃肠道：单形性上皮样肠道T细胞淋巴瘤的内镜检查结果。
J Gastroenterol Hepatol. 2019 Feb;34(2):311. doi: 10.1111/jgh.14474. Epub 2018 Oct 10.
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Incidental Diagnosis of Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma: A Case Report.单形上皮样肠道T细胞淋巴瘤的偶然诊断：一例报告
Cureus. 2020 Aug 27;12(8):e10084. doi: 10.7759/cureus.10084.

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Leptomeningitis as Rare Secondary Dissemination in MEITL (Monomorphic Intestinal Epitheliotropic T-Cell Lymphoma).柔脑膜炎症作为肠病型T细胞淋巴瘤（单形性肠道上皮嗜T细胞淋巴瘤）罕见的继发性播散表现
Life (Basel). 2025 Aug 5;15(8):1243. doi: 10.3390/life15081243.
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A rare case of monomorphic epitheliotropic intestinal T-cell lymphoma, presenting with spontaneous intestinal perforation.一例罕见的单形性亲上皮性肠道T细胞淋巴瘤，表现为自发性肠穿孔。
Int J Surg Case Rep. 2024 Nov;124:110485. doi: 10.1016/j.ijscr.2024.110485. Epub 2024 Oct 20.
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Monomorphic epitheliotropic intestinal T-cell lymphoma: report of four cases and literature review.单一表型上皮样肠道 T 细胞淋巴瘤：4 例报告及文献复习。
J Int Med Res. 2024 Aug;52(8):3000605241271756. doi: 10.1177/03000605241271756.
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Clinicopathological and molecular genetic alterations in monomorphic-epitheliotropic intestinal T-cell lymphoma of the small intestine.小肠单一上皮型肠黏膜相关 T 细胞淋巴瘤的临床病理和分子遗传学改变。
Eur J Med Res. 2024 Mar 23;29(1):191. doi: 10.1186/s40001-024-01797-5.
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Biology and genetics of extranodal mature T-cell and NKcell lymphomas and lymphoproliferative disorders.结外成熟 T 细胞和 NK 细胞淋巴瘤和淋巴增殖性疾病的生物学和遗传学。
Haematologica. 2023 Dec 1;108(12):3261-3277. doi: 10.3324/haematol.2023.282718.
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Few and far between: clinical management of rare extranodal subtypes of mature T-cell and NK-cell lymphomas.寥寥无几：罕见结外成熟 T 细胞和 NK 细胞淋巴瘤的临床处理方法。
Haematologica. 2023 Dec 1;108(12):3244-3260. doi: 10.3324/haematol.2023.282717.
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SOHO State of the Art Updates and Next Questions | Challenging Cases in Rare T-Cell Lymphomas.SOHO 最新进展及未来展望 | 罕见 T 细胞淋巴瘤中的挑战性病例。
Clin Lymphoma Myeloma Leuk. 2023 Sep;23(9):642-650. doi: 10.1016/j.clml.2023.05.012. Epub 2023 May 23.
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SOHO State of the Art Updates and Next Questions | New Pathways and New Targets in PTCL: Staying on Target.SOHO 最新进展与未来展望 | 探讨新途径与新靶点，以实现 PTCL 精准治疗：稳扎稳打。
Clin Lymphoma Myeloma Leuk. 2023 Aug;23(8):561-574. doi: 10.1016/j.clml.2023.04.007. Epub 2023 Apr 19.
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Emerging predictive biomarkers for novel therapeutics in peripheral T-cell and natural killer/T-cell lymphoma.外周 T 细胞和自然杀伤/T 细胞淋巴瘤新型治疗药物的新兴预测性生物标志物。
Front Immunol. 2023 Jan 26;14:1068662. doi: 10.3389/fimmu.2023.1068662. eCollection 2023.
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Rational drug combination design in patient-derived avatars reveals effective inhibition of hepatocellular carcinoma with proteasome and CDK inhibitors.基于患者来源类器官的理性药物组合设计揭示蛋白酶体和 CDK 抑制剂抑制肝癌的有效性。
J Exp Clin Cancer Res. 2022 Aug 15;41(1):249. doi: 10.1186/s13046-022-02436-9.

本文引用的文献

1
Application of an ex-vivo drug sensitivity platform towards achieving complete remission in a refractory T-cell lymphoma.应用体外药物敏感性平台实现难治性T细胞淋巴瘤的完全缓解。
Blood Cancer J. 2020 Jan 27;10(1):9. doi: 10.1038/s41408-020-0276-7.
2
Survival benefit in patients with peripheral T-cell lymphomas after treatments with novel therapies and clinical trials.新型疗法和临床试验治疗外周 T 细胞淋巴瘤患者的生存获益。
Hematol Oncol. 2020 Feb;38(1):51-58. doi: 10.1002/hon.2705. Epub 2019 Dec 29.
3
Multicenter retrospective analysis of the clinicopathologic features of monomorphic epitheliotropic intestinal T-cell lymphoma.多中心回顾性分析单一表型上皮亲嗜性肠 T 细胞淋巴瘤的临床病理特征。
Ann Hematol. 2019 Nov;98(11):2541-2550. doi: 10.1007/s00277-019-03791-y. Epub 2019 Sep 6.
4
Optimizing drug combinations against multiple myeloma using a quadratic phenotypic optimization platform (QPOP).利用二次表型优化平台（QPOP）优化多发性骨髓瘤的药物组合。
Sci Transl Med. 2018 Aug 8;10(453). doi: 10.1126/scitranslmed.aan0941.
5
Mutalisk: a web-based somatic MUTation AnaLyIS toolKit for genomic, transcriptional and epigenomic signatures.Mutalisk：一个基于网络的体细胞突变分析工具包，用于基因组、转录组和表观基因组特征。
Nucleic Acids Res. 2018 Jul 2;46(W1):W102-W108. doi: 10.1093/nar/gky406.
6
STAT5 inhibition induces TRAIL/DR4 dependent apoptosis in peripheral T-cell lymphoma.信号转导和转录激活因子5（STAT5）抑制可诱导外周T细胞淋巴瘤中肿瘤坏死因子相关凋亡诱导配体（TRAIL）/死亡受体4（DR4）依赖性凋亡。
Oncotarget. 2018 Mar 30;9(24):16792-16806. doi: 10.18632/oncotarget.24698.
7
Novel findings from the Asian Lymphoma Study Group: focus on T and NK-cell lymphomas.亚洲淋巴瘤研究组的新发现：聚焦于T细胞和NK细胞淋巴瘤。
Int J Hematol. 2018 Apr;107(4):413-419. doi: 10.1007/s12185-018-2406-6. Epub 2018 Jan 29.
8
Epstein-Barr virus-associated primary nodal T/NK-cell lymphoma shows a distinct molecular signature and copy number changes.EB 病毒相关原发性结内 T/NK 细胞淋巴瘤具有独特的分子特征和拷贝数改变。
Haematologica. 2018 Feb;103(2):278-287. doi: 10.3324/haematol.2017.180430. Epub 2017 Nov 2.
9
Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations.II 型肠病相关 T 细胞淋巴瘤具有独特的基因组特征，高度重现 SETD2 改变。
Nat Commun. 2016 Sep 7;7:12602. doi: 10.1038/ncomms12602.
10
DDGP versus SMILE in Newly Diagnosed Advanced Natural Killer/T-Cell Lymphoma: A Randomized Controlled, Multicenter, Open-label Study in China.DDGP 方案与 SMILE 方案治疗初治中高危 NK/T 细胞淋巴瘤的随机对照、多中心、开放标签研究 **解析**：原文是一篇医学研究论文的标题，包含了医学专业术语“Natural Killer/T-Cell Lymphoma”，意思是“自然杀伤/T 细胞淋巴瘤”。译文忠实反映了原文的内容，准确传达了其含义。
Clin Cancer Res. 2016 Nov 1;22(21):5223-5228. doi: 10.1158/1078-0432.CCR-16-0153. Epub 2016 Apr 8.

全基因组测序揭示了单形性上皮样肠道T细胞淋巴瘤的有效治疗策略。

Whole-genome sequencing reveals potent therapeutic strategy for monomorphic epitheliotropic intestinal T-cell lymphoma.

作者信息

Huang Dachuan, Lim Jing Quan, Cheah Daryl Ming Zhe, Kahliab Khalilatul Hanisah Binte Mohd, Laurensia Yurike, Pang Jane Wan Lu, Wong Esther Kam Yin, Chia Burton Kuan Hui, Goh Jasmine, Zhang Xiyun, Chan Jason Yongsheng, Chow Edward Kai-Hua, Tan Soo Yong, Lim Soon Thye, Ong Choon Kiat

机构信息

Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, National Cancer Centre, Singapore.

Duke-NUS Medical School, Singapore.

出版信息

Blood Adv. 2020 Oct 13;4(19):4769-4774. doi: 10.1182/bloodadvances.2020001782.

DOI:10.1182/bloodadvances.2020001782
PMID:33017466
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7556141/
Abstract

Whole genomic and transcriptomic analyses of MEITL revealed multiple potential therapeutic targets. Synergistic effects of pimozide and romidepsin are shown in a well-characterized MEITL PDX model.

摘要

对肠病相关T细胞淋巴瘤（MEITL）的全基因组和转录组分析揭示了多个潜在治疗靶点。在一个特征明确的MEITL人源肿瘤异种移植（PDX）模型中显示了匹莫齐特和罗米地辛的协同作用。