Ishimura K, Senda T, Kitajima K, Fujita H, Fujio Y, Sobue K
Histochemistry. 1987;86(6):537-9. doi: 10.1007/BF00489544.
The localization of calspectin (fodrin, a non-erythroid spectrin-like protein), which is known to bind calmodulin and F-actin, was detected in the thyroid gland of normal and TSH-treated rats by means of light-microscopic immunocytochemistry. Calspectin was demonstrated in the cytoplasm of the follicle epithelial cells especially along the baso-lateral plasma membrane in normal rats. In TSH-treated animals, in addition to the baso-lateral plasma membrane region, the apical plasma membrane region of the follicle epithelial cells also showed positive reaction to the immunostaining. These results suggest that calspectin, in conjugation with calmodulin and actin, play a role in the secretory activities including reabsorption activity of colloid of the follicle epithelial cell.
钙视蛋白（ fodrin，一种非红细胞血影蛋白样蛋白）已知可结合钙调蛋白和F-肌动蛋白，通过光学显微镜免疫细胞化学方法在正常大鼠和促甲状腺激素（TSH）处理的大鼠甲状腺中检测到其定位。在正常大鼠中，钙视蛋白在滤泡上皮细胞的细胞质中得到证实，特别是沿基底外侧质膜分布。在TSH处理的动物中，除基底外侧质膜区域外，滤泡上皮细胞的顶端质膜区域对免疫染色也呈阳性反应。这些结果表明，钙视蛋白与钙调蛋白和肌动蛋白结合，在包括滤泡上皮细胞胶体重吸收活性在内的分泌活动中发挥作用。
