Bazgir Behzad, Fathi Rouhollah, Rezazadeh Valojerdi Mojtaba, Mozdziak Paul, Asgari Alireza
Exercise Physiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Cell J. 2017 Winter;18(4):473-484. doi: 10.22074/cellj.2016.4714. Epub 2016 Sep 26.
Satellite cells (SCs) are the most abundant skeletal muscle stem cells. They are widely recognized for their contributions to maintenance of muscle mass, regeneration and hypertrophy during the human life span. These cells are good candidates for cell therapy due to their self-renewal capabilities and presence in an undifferentiated form. Presently, a significant gap exists between our knowledge of SCs behavior and their application as a means for human skeletal muscle tissue repair and regeneration. Both physiological and pathological stimuli potentially affect SCs activation, proliferation, and terminal differentiation the former category being the focus of this article. Activation of SCs occurs following exercise, post-training micro-injuries, and electrical stimulation. Exercise, as a potent and natural stimulus, is at the center of numerous studies on SC activation and relevant fields. According to research, different exercise modalities end with various effects. This review article attempts to picture the state of the art of the SCs life span and their engagement in muscle regeneration and hypertrophy in exercise.
卫星细胞（SCs）是最丰富的骨骼肌干细胞。它们因其在人类生命周期中对维持肌肉质量、再生和肥大的贡献而被广泛认可。由于这些细胞具有自我更新能力且以未分化形式存在，因此是细胞治疗的良好候选者。目前，我们对卫星细胞行为的了解与将其作为人类骨骼肌组织修复和再生手段的应用之间存在显著差距。生理和病理刺激都可能影响卫星细胞的激活、增殖和终末分化，本文重点关注前者。卫星细胞的激活发生在运动、训练后微损伤和电刺激之后。运动作为一种强大的自然刺激，是众多关于卫星细胞激活及相关领域研究的核心。根据研究，不同的运动方式会产生不同的效果。这篇综述文章试图描绘卫星细胞生命周期的最新状况以及它们在运动中参与肌肉再生和肥大的情况。
