Gunaratnam Sejal, Talluri Dinakar, Greene Patrick, Sacre Pierre, Gonzalez-Martinez Jorge, Sarma Sridevi V
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:1035-1038. doi: 10.1109/EMBC44109.2020.9175721.
During gambling, humans often begin by making decisions based on expected rewards and expected risks. However, expectations may not match actual outcomes. As gamblers keep track of their performance, they may feel more or less lucky, which then influences future betting decisions. Studies have identified the orbitofrontal cortex (OFC) as a brain region that plays a significant role during risky decision making in humans. However, most human studies infer neural activation from functional magnetic resonance imaging (fMRI), which has a poor temporal resolution. In particular, fMRI cannot detect activity from neuronal populations in the OFC, which may encode specific information about how a subject reacts to mismatched outcomes. In this preliminary study, four human subjects participated in a gambling task while local field potentials (LFPs), captured at a millisecond resolution, were recorded from the OFC. We analyzed high-frequency activity (HFA: >70 Hz) in the LFPs, as HFA has been shown to correlate to activation of neuronal populations. In 3 out of 4 subjects, HFA in OFC modulated between matched and mismatched trials as soon as the outcome of each bet was revealed, with modulations occurring at different times and directions depending on the anatomical location within the OFC.
在赌博过程中，人类通常首先根据预期奖励和预期风险做出决策。然而，预期可能与实际结果不符。随着赌徒跟踪自己的表现，他们可能会或多或少地感到幸运，这进而影响未来的投注决策。研究已确定眶额皮质（OFC）是人类在风险决策过程中发挥重要作用的脑区。然而，大多数人体研究是从功能磁共振成像（fMRI）推断神经激活情况，其时间分辨率较差。特别是，fMRI无法检测眶额皮质中神经元群体的活动，而这些神经元群体可能编码有关受试者对不匹配结果如何反应的特定信息。在这项初步研究中，四名受试者参与了一项赌博任务，同时从眶额皮质记录以毫秒分辨率捕获的局部场电位（LFP）。我们分析了局部场电位中的高频活动（HFA：>70Hz），因为高频活动已被证明与神经元群体的激活相关。在4名受试者中的3名中，一旦每次投注的结果揭晓，眶额皮质中的高频活动就在匹配和不匹配试验之间进行调制，调制根据眶额皮质内的解剖位置在不同时间和方向发生。
