Annu Int Conf IEEE Eng Med Biol Soc. 2022 Jul;2022:807-811. doi: 10.1109/EMBC48229.2022.9871849.
Executive function (EF) consists of higher level cognitive processes including working memory, cognitive flexibility, and inhibition which together enable goal-directed behaviors. Many neurological disorders are associated with EF dysfunctions which can lead to suboptimal behavior. To assess the roles of these processes, we introduce a novel behavioral task and modeling approach. The gamble-like task, with sub-tasks targeting different EF capabilities, allows for quantitative assessment of the main components of EF. We demonstrate that human participants exhibit dissociable variability in the component processes of EF. These results will allow us to map behavioral outcomes to EEG recordings in future work in order to map brain networks associated with EF deficits. Clinical relevance- This work will allow us to quantify EF deficits and corresponding brain activity in patient populations in future work.
执行功能（EF）包括更高层次的认知过程，包括工作记忆、认知灵活性和抑制，这些共同使目标导向行为成为可能。许多神经疾病都与 EF 功能障碍有关，这可能导致行为不佳。为了评估这些过程的作用，我们引入了一种新的行为任务和建模方法。类似于赌博的任务，具有针对不同 EF 能力的子任务，允许对 EF 的主要成分进行定量评估。我们证明，人类参与者在 EF 成分过程中表现出可分离的变异性。这些结果将使我们能够在未来的工作中将行为结果映射到 EEG 记录上，以绘制与 EF 缺陷相关的大脑网络。临床意义-这项工作将使我们能够在未来的工作中量化患者群体的 EF 缺陷和相应的大脑活动。
