Meshram Nirvedh H, Jackson Daren, Mitchell Carol C, Wilbrand Stephanie M, Dempsey Robert J, Hermann Bruce P, Varghese Tomy
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:2088-2091. doi: 10.1109/EMBC44109.2020.9175911.
A relationship between ultrasound strain indices in carotid plaque to cognitive domains of executive and language function are studied in 42 symptomatic and 34 asymptomatic patients. The mean and standard deviation of the percentage stenosis were 72.10 ± 15.19 and 77.41 ± 11.20 for symptomatic and asymptomatic patients respectively. Pearson's correlation between axial, lateral and shear strain indices versus executive and language composite scores was performed.. A significant inverse correlation for both executive and language function for symptomatic patients to strain indices was found. On the other hand, for asymptomatic patients only executive function was inversely correlated with the corresponding strain indices. Our hypothesis that microemboli from vulnerable plaque and possible 'silent strokes' may be responsible for decline in executive function for both symptomatic and asymptomatic patients'. Strokes and transient ischemic attacks may be responsible for further cognitive decline in language function for symptomatic patients.
在42例有症状患者和34例无症状患者中，研究了颈动脉斑块的超声应变指数与执行功能和语言功能等认知领域之间的关系。有症状患者和无症状患者的狭窄百分比均值及标准差分别为72.10±15.19和77.41±11.20。对轴向、横向和剪切应变指数与执行功能及语言综合评分进行了Pearson相关性分析。发现有症状患者的执行功能和语言功能与应变指数均存在显著负相关。另一方面，对于无症状患者，仅执行功能与相应的应变指数呈负相关。我们的假设是，来自易损斑块的微栓子和可能的“无症状性卒中”可能是有症状和无症状患者执行功能下降的原因。卒中及短暂性脑缺血发作可能是有症状患者语言功能进一步认知衰退的原因。
