Meshram N H, Jackson D, Varghese T, Mitchell C C, Wilbrand S M, Dempsey R J, Hermann B P
Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Department of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI, USA.
Arch Clin Neuropsychol. 2019 Jan 24;35(1):46-55. doi: 10.1093/arclin/acz006.
We examine the relationship between variability in the plaque strain distribution estimated using ultrasound with multiple cognitive domains including executive, language, visuospatial reasoning, and memory function.
Asymptomatic (n = 42) and symptomatic (n = 34) patients with significant (>60%) carotid artery stenosis were studied for plaque instability using ultrasound strain imaging and multiple cognitive domains including executive, language, visuospatial reasoning, and memory function. Correlation and ROC analyses were performed between ultrasound strain indices and cognitive function. Strain indices and cognition scores were also compared between symptomatic and asymptomatic patients to determine whether there are significant group differences.
Association of high-strain distributions with dysexecutive function was observed in both asymptomatic and symptomatic patients. For memory, visuospatial, and language functions, the correlations between strain and cognition were weaker for the asymptomatic compared to symptomatic group.
Both asymptomatic and symptomatic patients demonstrate a relationship between vessel strain indices and executive function indicating that silent strokes and micro-emboli could initially contribute to a decline in executive function, whereas strokes and transient ischemic attacks may cause the further decline in other cognitive functions.
我们研究了使用超声估计的斑块应变分布变异性与包括执行功能、语言、视觉空间推理和记忆功能在内的多个认知领域之间的关系。
对有显著（>60%）颈动脉狭窄的无症状（n = 42）和有症状（n = 34）患者，使用超声应变成像以及包括执行功能、语言、视觉空间推理和记忆功能在内的多个认知领域来研究斑块不稳定性。对超声应变指标与认知功能进行相关性和ROC分析。还比较了有症状和无症状患者之间的应变指标和认知分数，以确定是否存在显著的组间差异。
在无症状和有症状患者中均观察到高应变分布与执行功能障碍之间的关联。对于记忆、视觉空间和语言功能，与有症状组相比，无症状组中应变与认知之间的相关性较弱。
无症状和有症状患者均表现出血管应变指标与执行功能之间的关系，表明无症状性卒中和微栓子最初可能导致执行功能下降，而卒中和短暂性脑缺血发作可能导致其他认知功能进一步下降。
