Ficiara E, D'Agata F, Ansari S, Boschi S, Rainero I, Priano L, Cattaldo S, Abollino O, Cavalli R, Guiot C
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:2270-2273. doi: 10.1109/EMBC44109.2020.9175988.
Iron plays important roles in healthy brain but altered homeostasis and concentration have been correlated to aging and neurodegenerative diseases. Iron enters the central nervous system by crossing the brain barrier systems: the Blood- Brain Barrier separating blood and brain and the Blood-Cerebrospinal Fluid Barrier (BCSFB) between blood and CSF, which is in contact with the brain by far less selective barriers. Herein, we develop a two-compartmental model for the BCSFB, based on first-order ordinary differential equations, performing numerical simulations and sensitivity analysis. Furthermore, as input parameters of the model, experimental data from patients affected by Alzheimer's disease, frontotemporal dementia, mild cognitive impairment and matched neurological controls were used, with the aim of investigating the differences between physiological and pathological conditions in the regulation of iron passage between blood and CSF which can be possibly targeted by therapy.
铁在健康大脑中发挥着重要作用，但体内平衡和浓度的改变与衰老和神经退行性疾病相关。铁通过跨越脑屏障系统进入中枢神经系统：血脑屏障分隔血液和大脑，血脑脊液屏障（BCSFB）位于血液和脑脊液之间，脑脊液通过选择性低得多的屏障与大脑接触。在此，我们基于一阶常微分方程开发了一种用于血脑脊液屏障的双室模型，进行数值模拟和敏感性分析。此外，作为模型的输入参数，使用了来自阿尔茨海默病、额颞叶痴呆、轻度认知障碍患者以及匹配的神经学对照的实验数据，目的是研究血液和脑脊液之间铁转运调节中生理和病理状况的差异，这些差异可能是治疗的靶点。
