Paknahad Javad, Loizos Kyle, Humayun Mark, Lazzi Gianluca
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:3393-3398. doi: 10.1109/EMBC44109.2020.9176125.
Electrical stimulation of surviving retinal neurons has proven effective in restoring sight to totally blind patients affected by retinal degenerative diseases. Morphological and biophysical differences among retinal ganglion cells (RGCs) are important factors affecting their response to epiretinal electrical stimulation. Although detailed models of ON and OFF RGCs have already been investigated, here we developed morphologically and biophysically realistic computational models of two classified RGCs, D1-bistratified and A2-monostratified, and analyzed their response to alternations in stimulation frequency (up to 200 Hz). Results show that the D1-bistratified cell is more responsive to high frequency stimulation compared to the A2-monostratified cell. This differential RGCs response suggests a potential avenue for selective activation, and in turn different encoded percept of RGCs.
对存活的视网膜神经元进行电刺激已被证明能有效恢复因视网膜退行性疾病而完全失明患者的视力。视网膜神经节细胞（RGCs）之间的形态和生物物理差异是影响其对视网膜上电刺激反应的重要因素。尽管已经对ON和OFF RGCs的详细模型进行了研究，但在此我们构建了两种分类的RGCs（D1-双分层和A2-单分层）的形态和生物物理逼真的计算模型，并分析了它们对刺激频率变化（高达200Hz）的反应。结果表明，与A2-单分层细胞相比，D1-双分层细胞对高频刺激更敏感。这种不同的RGCs反应提示了一条选择性激活的潜在途径，进而提示了RGCs不同编码感知的潜在途径。
