a Department of Biomedical Engineering , The University of Melbourne , Melbourne , Australia.
b Department of Neurology, Massachusetts General Hospital , Harvard Medical School , Boston , USA.
Network. 2017;28(2-4):74-93. doi: 10.1080/0954898X.2018.1455993.
There are more than 15 different types of retinal ganglion cells (RGCs) in the mammalian retina. To model responses of RGCs to electrical stimulation, we use single-compartment Hodgkin-Huxley-type models and run simulations in the Neuron environment. We use our recently published in vitro data of different morphological cell types to constrain the model, and study the effects of electrophysiology on the cell responses separately from the effects of morphology. We find simple models that can match the spike patterns of different types of RGCs. These models, with different input-output properties, may be used in a network to study retinal network dynamics and interactions.
哺乳动物视网膜中存在超过 15 种不同类型的视网膜神经节细胞（RGC）。为了模拟 RGC 对电刺激的反应，我们使用单室 Hodgkin-Huxley 型模型并在 Neuron 环境中进行模拟。我们使用最近发表的不同形态细胞类型的体外数据来约束模型，并分别研究电生理学对细胞反应的影响和形态对细胞反应的影响。我们发现了一些简单的模型，可以匹配不同类型 RGC 的尖峰模式。这些模型具有不同的输入-输出特性，可以在网络中用于研究视网膜网络的动态和相互作用。
