O'Clock George D, Strouse Watt Wendy
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:4967-4973. doi: 10.1109/EMBC44109.2020.9175325.
An understanding of healing processes for different tissues and organs, along with the development of appropriate therapeutic devices and treatment protocols, requires an appreciation for the mechanisms-of-action and sequencing of many interconnected chemical, electrical, mechanical, and optical activities. Unfortunately, the substantial contributions that endogenous electrical mechanisms-of-action provide in healing and regulation are often overlooked, resulting in a poor transfer of knowledge from science, to engineering, and finally, to therapy. The wide variety of healing processes, their therapeutic implications, and the devices and protocol designs that are most effective cannot be understood or addressed adequately without an understanding of the endogenous electrical mechanisms-of-action associated with wound healing. Achieving this level of understanding can be enhanced by the use of appropriate models and simulations that are based on physiological/biochemical system response characteristics.
要了解不同组织和器官的愈合过程，并开发合适的治疗设备和治疗方案，就需要认识许多相互关联的化学、电、机械和光学活动的作用机制及顺序。不幸的是，内源性电作用机制在愈合和调节过程中所做出的重大贡献常常被忽视，导致知识从科学到工程，最终到治疗的转化效果不佳。如果不了解与伤口愈合相关的内源性电作用机制，就无法充分理解和应对各种各样的愈合过程、它们的治疗意义以及最有效的设备和方案设计。通过使用基于生理/生化系统反应特征的适当模型和模拟，可以加深对这一水平的理解。
