Gentzkow G D, Miller K H
Staodyn, Inc., Longmont, Colorado.
Clin Podiatr Med Surg. 1991 Oct;8(4):827-41.
The investigations of biologic actions (in vitro, animal, and human) demonstrated several effects that help explain why electrical stimulation works. Based on the latest scientific understanding of the wound healing process, one would expect that a therapy that decreases edema, debrides necrotic tissue, attracts neutrophils and macrophages, stimulates receptor sites for growth factors, stimulates growth of fibroblasts and granulation tissue, increases blood flow, stimulates neurite growth, induces epidermal cell migration, prevents postischemic oxygen radical-mediated damage, inhibits bacteria, and reduces numbers of mast cells ought to be beneficial for wound healing. Numerous human and animal efficacy studies confirm that electrical stimulation of the proper charge, density, and total energy causes dramatically improved healing of dermal wounds. As of this writing, no devices have yet been approved by the FDA for use in wound healing, although several devices approved for other indications are being used for this purpose. One device (the Staodyn Dermapulse) has undergone controlled animal and human testing, and an application requesting approval for treating dermal ulcers has been submitted to FDA. Taken together, the efficacy studies and the "mechanism of action" studies provide compelling, scientific evidence that electrical stimulation is safe and effective for promoting the healing of dermal wounds.
对生物作用（体外、动物和人体）的研究表明了几种效应，这些效应有助于解释电刺激为何有效。基于对伤口愈合过程的最新科学认识，人们会预期一种能减轻水肿、清创坏死组织、吸引中性粒细胞和巨噬细胞、刺激生长因子的受体位点、刺激成纤维细胞和肉芽组织生长、增加血流量、刺激神经突生长、诱导表皮细胞迁移、防止缺血后氧自由基介导的损伤、抑制细菌并减少肥大细胞数量的疗法应该对伤口愈合有益。大量的人体和动物疗效研究证实，适当电荷、密度和总能量的电刺激可显著改善皮肤伤口的愈合。截至撰写本文时，尚无设备获得美国食品药品监督管理局（FDA）批准用于伤口愈合，尽管一些已获批准用于其他适应症的设备正被用于此目的。一种设备（Staodyn Dermapulse）已进行了对照动物和人体测试，一份治疗皮肤溃疡的批准申请已提交给FDA。综合来看，疗效研究和“作用机制”研究提供了令人信服的科学证据，证明电刺激对促进皮肤伤口愈合是安全有效的。
