Giglio Nicholas C, Hutchens Thomas C, Wilson Christopher R, Gonzalez David A, Fried Nathaniel M
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:5045-5048. doi: 10.1109/EMBC44109.2020.9176236.
The Thulium fiber laser (TFL) is being explored as a potential alternative to the gold standard Holmium:YAG laser for infrared laser ablation of kidney stones. Laser-induced vapor bubbles contribute to both the ablation mechanism and stone retropulsion. In this preliminary study, a biocompatible surfactant with concentrations of 1-5% was used to enhance the vapor bubble dimensions during the laser pulse. Bubble dimensions using surfactant increased on average by 25% compared with water only (control). With further development, introduction of the surfactant into the saline irrigation flow typically delivered through the working channel of the ureteroscope during laser lithotripsy, may contribute to more efficient stone ablation.Clinical Relevance-This preliminary study demonstrates that the dimensions of laser-induced vapor bubbles created during infrared laser lithotripsy can be enhanced by up to 25%, for potential clinical translation into more efficient lithotripsy and use in the "popcorn" ablation method.
铥光纤激光器（TFL）正在被探索作为用于肾结石红外激光消融的金标准钬激光的潜在替代方案。激光诱导的蒸汽泡对消融机制和结石后推都有作用。在这项初步研究中，使用浓度为1%至5%的生物相容性表面活性剂来在激光脉冲期间增大蒸汽泡尺寸。与仅用水（对照）相比，使用表面活性剂时气泡尺寸平均增加了25%。随着进一步发展，将表面活性剂引入通常在激光碎石术期间通过输尿管镜工作通道输送的盐水冲洗流中，可能有助于更有效地进行结石消融。临床意义——这项初步研究表明，在红外激光碎石术期间产生的激光诱导蒸汽泡的尺寸可增大多达25%，有可能在临床上转化为更有效的碎石术并用于“爆米花”消融方法。
