Roy Zachary, Subhash Sujit, Bui Lien A, Hadi Bassam, Hier Daniel B, Wunsch Donald, Olbricht Gayla R, Obafemi-Ajayi Tayo
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:5514-5518. doi: 10.1109/EMBC44109.2020.9176527.
Clinicians need better tools to assess severity, prognosis, and recovery from mild Traumatic Brain Injury (mTBI), which can cause long term impairment. To enable better mTBI outcome prediction, an initial step is to analyze the trajectory of recovery metrics over time. This study provides an assessment of recovery trajectories of mTBI while incorporating heterogeneity of individual responses. We analyze the trajectories over multiple discrete time points from baseline to 6 months post injury using a combination of neurocognitive and postural stability assessments and serum biomarkers. The data, obtained from FITBIR, consists of concussed subjects and a matched control group, to allow for comparison in prognostic assessment. Outcomes derived from this exploratory analysis will aid future studies in developing a mTBI recovery timeline model.Clinical relevance- This study further informs clinicians as to the recovery trajectory of clinical measures and biomarkers after mTBI to support return to play decisions. GFAP biomarker and measures related to balance, memory, orientation, and concentration were significantly different than controls early after mTBI.
临床医生需要更好的工具来评估轻度创伤性脑损伤（mTBI）的严重程度、预后和恢复情况，mTBI可能会导致长期损伤。为了实现更好的mTBI结果预测，第一步是分析恢复指标随时间的变化轨迹。本研究在纳入个体反应异质性的同时，对mTBI的恢复轨迹进行了评估。我们使用神经认知和姿势稳定性评估以及血清生物标志物的组合，分析了从基线到受伤后6个月的多个离散时间点的轨迹。从FITBIR获得的数据包括脑震荡受试者和匹配的对照组，以便在预后评估中进行比较。这项探索性分析得出的结果将有助于未来研究建立mTBI恢复时间线模型。临床相关性——本研究进一步告知临床医生mTBI后临床测量和生物标志物的恢复轨迹，以支持重返比赛的决策。mTBI后早期，GFAP生物标志物以及与平衡、记忆、定向和注意力相关的测量结果与对照组有显著差异。
