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Active Folate Versus Folic Acid: The Role of 5-MTHF (Methylfolate) in Human Health.

作者信息

Carboni Lorena

出版信息

Integr Med (Encinitas). 2022 Jul;21(3):36-41.

PMID:35999905
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9380836/
Abstract
摘要

相似文献

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Active Folate Versus Folic Acid: The Role of 5-MTHF (Methylfolate) in Human Health.活性叶酸与叶酸：5-甲基四氢叶酸（甲基叶酸）在人类健康中的作用
Integr Med (Encinitas). 2022 Jul;21(3):36-41.
2
Red blood cell folate concentrations increase more after supplementation with [6S]-5-methyltetrahydrofolate than with folic acid in women of childbearing age.在育龄女性中，补充[6S]-5-甲基四氢叶酸后红细胞叶酸浓度的增加幅度大于补充叶酸后的增加幅度。
Am J Clin Nutr. 2006 Jul;84(1):156-61. doi: 10.1093/ajcn/84.1.156.
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Wheat rolls fortified with microencapsulated L-5-methyltetrahydrofolic acid or equimolar folic acid increase blood folate concentrations to a similar extent in healthy men and women.小麦卷经微囊化 L-5-甲基四氢叶酸或等摩尔叶酸强化后，可使健康男性和女性的血液叶酸浓度增加到相似的程度。
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Folic acid, but not folate, regulates different stages of neurogenesis in the ventral hippocampus of adult female rats.叶酸，而非叶酸盐，调节成年雌性大鼠腹侧海马体中不同阶段的神经发生。
J Neuroendocrinol. 2019 Oct;31(10):e12787. doi: 10.1111/jne.12787. Epub 2019 Oct 2.
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Enhanced oral bioavailability of a novel folate salt: comparison with folic acid and a calcium folate salt in a pharmacokinetic study in rats.一种新型叶酸盐的口服生物利用度增强：在大鼠药代动力学研究中与叶酸和叶酸钙盐的比较。
Minerva Ginecol. 2016 Apr;68(2):99-105.
6
Increases in blood folate indices are similar in women of childbearing age supplemented with [6S]-5-methyltetrahydrofolate and folic acid.补充[6S]-5-甲基四氢叶酸和叶酸的育龄妇女血液叶酸指标的增加情况相似。
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l-5-Methyltetrahydrofolate Supplementation Increases Blood Folate Concentrations to a Greater Extent than Folic Acid Supplementation in Malaysian Women.L-5-甲基四氢叶酸补充剂比叶酸补充剂更能增加马来西亚妇女血液中的叶酸浓度。
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Folate in depression: efficacy, safety, differences in formulations, and clinical issues.抑郁症中的叶酸：疗效、安全性、配方差异及临床问题。
J Clin Psychiatry. 2009;70 Suppl 5:12-7. doi: 10.4088/JCP.8157su1c.03.
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Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women.补充[6S]-5-甲基四氢叶酸或叶酸对降低健康女性血浆总同型半胱氨酸浓度的效果相同。
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Folic acid versus 5- methyl tetrahydrofolate supplementation in pregnancy.孕期补充叶酸与5-甲基四氢叶酸的比较
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Exploring the Impact of Folic Acid Supplementation and Vitamin B12 Deficiency on Maternal and Fetal Outcomes in Pregnant Women with Celiac Disease.探讨叶酸补充和维生素 B12 缺乏对乳糜泻孕妇母婴结局的影响。
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本文引用的文献

1
Folic Acid, Folinic Acid, 5 Methyl TetraHydroFolate Supplementation for Mutations That Affect Epigenesis through the Folate and One-Carbon Cycles.叶酸、亚叶酸、5-甲基四氢叶酸补充剂可用于影响叶酸和一碳循环的表观遗传学的突变。
Biomolecules. 2022 Jan 24;12(2):197. doi: 10.3390/biom12020197.
2
5-Methyltetrahydrofolate and Vitamin B12 Supplementation Is Associated with Clinical Pregnancy and Live Birth in Women Undergoing Assisted Reproductive Technology.5-甲基四氢叶酸和维生素 B12 补充与接受辅助生殖技术的女性的临床妊娠和活产有关。
Int J Environ Res Public Health. 2021 Nov 23;18(23):12280. doi: 10.3390/ijerph182312280.
3
A Novel Review of Homocysteine and Pregnancy Complications.同型半胱氨酸与妊娠并发症的新综述
Biomed Res Int. 2021 May 6;2021:6652231. doi: 10.1155/2021/6652231. eCollection 2021.
4
Folates, folic acid and preconception care - a review.叶酸、叶酸和孕前保健——综述
JRSM Open. 2021 May 13;12(5):2054270420980875. doi: 10.1177/2054270420980875. eCollection 2021 May.
5
MTHFR (methylenetetrahydrofolate reductase: EC 1.5.1.20) SNPs (single-nucleotide polymorphisms) and homocysteine in patients referred for investigation of fertility.亚甲基四氢叶酸还原酶（MTHFR：EC1.5.1.20）单核苷酸多态性（SNP）与接受生育力检查的患者的同型半胱氨酸。
J Assist Reprod Genet. 2021 Sep;38(9):2383-2389. doi: 10.1007/s10815-021-02200-6. Epub 2021 Apr 29.
6
MTHFR 1298A>C Substitution is a Strong Candidate for Analysis in Recurrent Pregnancy Loss: Evidence from 14,289 Subjects.亚甲基四氢叶酸还原酶1298A>C替换是复发性流产分析的有力候选因素：来自14289名受试者的证据。
Reprod Sci. 2022 Apr;29(4):1039-1053. doi: 10.1007/s43032-021-00530-5. Epub 2021 Mar 19.
7
Maternal biomarkers for early prediction of the neural tube defects pregnancies.用于神经管缺陷妊娠早期预测的母体生物标志物。
Birth Defects Res. 2021 Apr 15;113(7):589-600. doi: 10.1002/bdr2.1842. Epub 2020 Nov 13.
8
Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop.理解过量叶酸/叶酸的代谢和临床影响方面的知识差距：NIH 研讨会的总结和观点。
Am J Clin Nutr. 2020 Nov 11;112(5):1390-1403. doi: 10.1093/ajcn/nqaa259.
9
Association between gene polymorphism of folate metabolism and recurrent spontaneous abortion in Asia: A Meta-analysis.亚洲人群叶酸代谢基因多态性与复发性自然流产的相关性：一项Meta分析。
Medicine (Baltimore). 2020 Oct 2;99(40):e21962. doi: 10.1097/MD.0000000000021962.
10
Folate Insufficiency Due to MTHFR Deficiency Is Bypassed by 5-Methyltetrahydrofolate.5-甲基四氢叶酸可绕过因亚甲基四氢叶酸还原酶（MTHFR）缺乏导致的叶酸不足。
J Clin Med. 2020 Sep 2;9(9):2836. doi: 10.3390/jcm9092836.