Chen Ying, Meng Liwei, Wang Liangchen, Xiao Li, Yang Caizhe
Department of Endocrinology of the Air Force Medical Center, PLA.
Department of Endocrinology of the Xiangyang District People's Hospital of Xiangyang City, China.
Medicine (Baltimore). 2020 Oct 2;99(40):e22334. doi: 10.1097/MD.0000000000022334.
This study aims to establish a diagnostic model of coronary heart disease (CHD) for diabetic foot (DF) patients.The clinical data of 489 hospitalized patients with DF were retrospectively analyzed in this case-control study. The patients were divided into the CHD group (DF with CHD, n = 212) and the control group (DF without CHD, n = 277). Univariate analysis was performed to screen for CHD-related risk factors, and multivariate logistic regression analysis was conducted to determine significant CHD risk factors. Scores were assigned according to the ratio of risk factors (OR) to establish a diagnostic model of CHD for patients with DF. The area under the ROC curve was used to test the application value of the diagnostic model.The logistic regression analysis showed that the risk factors for CHD in DF patients were age, duration of diabetes, toe-brachial index, hyperuricemia, and chronic renal insufficiency. The area under the ROC curve of the diagnostic model was 0.798 (0.759-0.837), the diagnostic point of CHD was 6 points, the diagnostic sensitivity was 69.3%, and the specificity was 76.5%.The established model has good diagnostic value and provides the basis for preliminary screening for CHD in patients with DF.
本研究旨在建立糖尿病足(DF)患者冠心病(CHD)的诊断模型。在这项病例对照研究中,对489例住院DF患者的临床资料进行回顾性分析。将患者分为冠心病组(合并冠心病的DF患者,n = 212)和对照组(无冠心病的DF患者,n = 277)。进行单因素分析以筛选与冠心病相关的危险因素,并进行多因素logistic回归分析以确定显著的冠心病危险因素。根据危险因素的比值比(OR)赋值,建立DF患者冠心病的诊断模型。采用ROC曲线下面积检验诊断模型的应用价值。logistic回归分析显示,DF患者冠心病的危险因素为年龄、糖尿病病程、趾臂指数、高尿酸血症和慢性肾功能不全。诊断模型的ROC曲线下面积为0.798(0.759 - 0.837),冠心病诊断切点为6分,诊断敏感性为69.3%,特异性为76.5%。所建立的模型具有良好的诊断价值,为DF患者冠心病的初步筛查提供了依据。