Crawford Kristina, Endara Matthew
Resident Physician, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Plastic Surgeon, Maury Regional Medical Group, Columbia, TN 38401, USA.
Medicina (Kaunas). 2020 Oct 1;56(10):516. doi: 10.3390/medicina56100516.
Radiation therapy is frequently a critical component of breast cancer care but carries with it side effects that are particularly damaging to reconstructive efforts. Autologous lipotransfer has the ability to improve radiated skin throughout the body due to the pluripotent stem cells and multiple growth factors transferred therein. The oncologic safety of lipotransfer to the breasts is demonstrated in the literature and is frequently considered an adjunctive procedure for improving the aesthetic outcomes of breast reconstruction. Using lipotransfer as an integral rather than adjunctive step in the reconstructive process for breast cancer patients requiring radiation results in improved complication rates equivalent to those of nonradiated breasts, expanding options in these otherwise complicated cases. Herein, we provide a detailed review of the cellular toxicity conferred by radiotherapy and describe at length our approach to autologous lipotransfer in radiated breasts.
放射治疗常常是乳腺癌治疗的关键组成部分，但它会带来一些副作用，对乳房重建造成特别大的损害。由于自体脂肪移植过程中转移了多能干细胞和多种生长因子，所以它有能力改善全身受辐射的皮肤。文献表明脂肪移植到乳房的肿瘤学安全性，并且它常被视为改善乳房重建美学效果的辅助手术。对于需要放疗的乳腺癌患者，在重建过程中将脂肪移植作为一个不可或缺而非辅助性的步骤，可使并发症发生率得到改善，与未受辐射的乳房相当，从而在这些原本复杂的病例中增加了选择。在此，我们详细回顾放疗所致的细胞毒性，并详细描述我们对受辐射乳房进行自体脂肪移植的方法。
