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药用植物在皮肤癌建模中的应用。

Medicinal Plants Towards Modeling Skin Cancer.

机构信息

Department of Anatomy, Cell Biology, and Physiological Sciences, American University of Beirut, Beirut, Lebanon.

Center for Stem Cell Research and Regenerative Medicine, Tulane University, New Orleans, LA 70112, United States.

出版信息

Curr Drug Targets. 2021;22(2):148-161. doi: 10.2174/1389450121666201005103521.

Abstract

Skin cancer remains a major cause of mortality worldwide. It can be divided into melanoma and non-melanoma cancer, which comprise mainly squamous cell carcinoma and basal cell carcinoma. Although conventional therapies have ameliorated the management of skin cancer, the search for chemopreventive compounds is still the most effective and safer strategy to treat cancer. Nowadays, chemoprevention is recognized as a novel approach to prevent or inhibit carcinogenesis steps with the use of natural products. Crude extracts of plants and isolated phytocompounds are considered chemopreventive agents since they harbor anti-inflammatory, antioxidant and anti-oncogenic properties against many types of diseases and cancers. In this review, we will discuss the therapeutic effect and preventive potential of selected medicinal plants used as crude extracts or as phytocompounds against melanoma and non-melanoma cutaneous cancers.

摘要

皮肤癌仍然是全球主要的死亡原因。它可以分为黑色素瘤和非黑色素瘤癌症,主要包括鳞状细胞癌和基底细胞癌。尽管传统疗法已经改善了皮肤癌的治疗,但寻找化学预防化合物仍然是治疗癌症最有效和更安全的策略。如今,化学预防被认为是一种预防或抑制使用天然产物的致癌作用步骤的新方法。植物的粗提取物和分离的植物化合物被认为是化学预防剂,因为它们具有抗炎、抗氧化和抗致癌特性,可以对抗多种疾病和癌症。在这篇综述中,我们将讨论一些药用植物的粗提取物或植物化合物作为治疗药物和预防皮肤癌的潜力,这些药用植物对黑色素瘤和非黑色素瘤皮肤癌具有治疗作用和预防潜力。

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