Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taipei, and Keelung 105, Taiwan.
Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taipei, and Keelung 105, Taiwan.
Int J Mol Sci. 2018 Mar 22;19(4):941. doi: 10.3390/ijms19040941.
Skin is the largest human organ, our protection against various environmental assaults and noxious agents. Accumulation of these stress events may lead to the formation of skin cancers, including both melanoma and non-melanoma skin cancers. Although modern targeted therapies have ameliorated the management of cutaneous malignancies, a safer, more affordable, and more effective strategy for chemoprevention and treatment is clearly needed for the improvement of skin cancer care. Phytochemicals are biologically active compounds derived from plants and herbal products. These agents appear to be beneficial in the battle against cancer as they exert anti-carcinogenic effects and are widely available, highly tolerated, and cost-effective. Evidence has indicated that the anti-carcinogenic properties of phytochemicals are due to their anti-oxidative, anti-inflammatory, anti-proliferative, and anti-angiogenic effects. In this review, we discuss the preventive potential, therapeutic effects, bioavailability, and structure-activity relationship of these selected phytochemicals for the management of skin cancers. The knowledge compiled here will provide clues for future investigations on novel oncostatic phytochemicals and additional anti-skin cancer mechanisms.
皮肤是人体最大的器官，是我们抵御各种环境侵袭和有害因素的第一道防线。这些应激事件的积累可能导致皮肤癌的形成，包括黑色素瘤和非黑色素瘤皮肤癌。尽管现代靶向疗法改善了皮肤恶性肿瘤的治疗管理，但显然需要更安全、更经济实惠、更有效的化学预防和治疗策略，以改善皮肤癌的治疗效果。植物化学物质是从植物和草药产品中提取的具有生物活性的化合物。这些物质似乎在抗癌方面具有益处，因为它们具有抗癌作用，并且广泛存在、高度耐受且具有成本效益。有证据表明，植物化学物质的抗癌特性归因于其抗氧化、抗炎、抗增殖和抗血管生成作用。在这篇综述中，我们讨论了这些选定的植物化学物质在皮肤癌管理中的预防潜力、治疗效果、生物利用度和构效关系。这里汇集的知识将为未来关于新型肿瘤抑制植物化学物质和其他皮肤癌防治机制的研究提供线索。
