肌萎缩侧索硬化症患者的血清胰岛素样生长因子-I水平
Serum insulin-like growth factor-I levels in amyotrophic lateral sclerosis.
作者信息
Braunstein G D, Reviczky A L
出版信息
J Neurol Neurosurg Psychiatry. 1987 Jun;50(6):792-4. doi: 10.1136/jnnp.50.6.792.
Abstract
The serum concentrations of the myotrophic hormone insulin-like growth factor-I (IGF-I) in 23 patients with amyotrophic lateral sclerosis were not significantly different from those found in the sera of 13 control patients. There was no difference in binding of 125I-IGF-I by serum from patients with amyotrophic lateral sclerosis in comparison with that found in the controls. These results indicate that immunoreactive IGF-I concentrations are normal in patients with amyotrophic lateral sclerosis and that such patients do not have significant antibodies binding their endogenous IGF-I.
摘要
23例肌萎缩侧索硬化患者血清中的肌营养激素胰岛素样生长因子-I（IGF-I）浓度与13例对照患者血清中的浓度无显著差异。与对照组相比，肌萎缩侧索硬化患者血清对125I-IGF-I的结合无差异。这些结果表明，肌萎缩侧索硬化患者免疫反应性IGF-I浓度正常，且此类患者不存在结合其内源性IGF-I的显著抗体。
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