Torres-Aleman I, Barrios V, Berciano J
Laboratory of Cellular and Molecular Neuroendocrinology, Instituto Cajal, CSIC, Madrid, Spain.
Neurology. 1998 Mar;50(3):772-6. doi: 10.1212/wnl.50.3.772.
A lack of trophic support may lead to degeneration of adult nerve cells. Several growth factors, including insulin-like growth factor I (IGF-I), control the survival of spinal motor neurons during development as well as after experimental injury. These neurons are selectively affected in patients with amyotrophic lateral sclerosis (ALS). Thus, we analyzed whether reduced levels of circulating IGF-I may be present in this disease. Significant increases were found in three of four of the main circulating IGF-binding proteins in ALS patients, whereas serum IGF-I and insulin levels were significantly reduced. On the contrary, multiple sclerosis patients did not show any significant change in the IGF-I trophic system even though oligodendrocytes are known targets of the trophic action of IGF-I. These results suggest an involvement of the peripheral IGF-I trophic system in ALS.
营养支持的缺乏可能导致成体神经细胞退化。包括胰岛素样生长因子I（IGF-I）在内的多种生长因子，在发育过程以及实验性损伤后控制脊髓运动神经元的存活。这些神经元在肌萎缩侧索硬化症（ALS）患者中受到选择性影响。因此，我们分析了这种疾病中循环IGF-I水平是否会降低。在ALS患者中，四种主要循环IGF结合蛋白中的三种显著增加，而血清IGF-I和胰岛素水平显著降低。相反，尽管少突胶质细胞是IGF-I营养作用的已知靶点，但多发性硬化症患者的IGF-I营养系统没有显示出任何显著变化。这些结果表明外周IGF-I营养系统参与了ALS。
