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胰岛素样生长因子I/生长调节素C（IGF-I/Sm C）：在两种放射性配体分析中天然、固相合成及重组DNA类似肽的比较

Insulin-like growth factor I/somatomedin C (IGF-I/Sm C): comparison of natural, solid phase synthetic and recombinant DNA analog peptides in two radioligand assays.

作者信息

Schalch D, Reismann D, Emler C, Humbel R, Li C H, Peters M, Lau E

出版信息

Endocrinology. 1984 Dec;115(6):2490-2. doi: 10.1210/endo-115-6-2490.

DOI:10.1210/endo-115-6-2490
PMID:6389098
Abstract

Investigation of the biologic activity of Insulin-like Growth Factor I/Somatomedin C (IGF-I/Sm C) has been hampered by the scarcity of purified material. The synthesis of this molecule by the solid phase procedure and an analog of IGF-I/Sm C by recombinant DNA technology offers promise that studies of the biologic activity of IGF-I/Sm C will soon be possible. We have found that natural IGF-I/Sm C and the two synthetic peptides behave similarly in two radioligand systems, providing evidence that these molecules possess the requisite structural integrity for use in such biological studies.

摘要

胰岛素样生长因子I/生长调节素C（IGF-I/Sm C）生物活性的研究因纯化材料的匮乏而受阻。通过固相法合成该分子以及利用重组DNA技术合成IGF-I/Sm C的类似物，为不久后开展IGF-I/Sm C生物活性研究带来了希望。我们发现，天然IGF-I/Sm C和这两种合成肽在两种放射性配体系统中的表现相似，这证明这些分子具备用于此类生物学研究所需的结构完整性。

相似文献

1
Insulin-like growth factor I/somatomedin C (IGF-I/Sm C): comparison of natural, solid phase synthetic and recombinant DNA analog peptides in two radioligand assays.胰岛素样生长因子I/生长调节素C（IGF-I/Sm C）：在两种放射性配体分析中天然、固相合成及重组DNA类似肽的比较
Endocrinology. 1984 Dec;115(6):2490-2. doi: 10.1210/endo-115-6-2490.
2
Evidence from radioligand assays that somatomedin-C and insulin-like growth factor-I are similar to each other and different from other somatomedins.放射配体分析的证据表明，生长调节素C和胰岛素样生长因子-I彼此相似，且与其他生长调节素不同。
J Clin Endocrinol Metab. 1980 Jan;50(1):206-8. doi: 10.1210/jcem-50-1-206.
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Isolation and partial characterization of six somatomedin-like peptides from human plasma Cohn fraction IV.从人血浆考恩IV组分中分离并部分鉴定六种类生长调节素肽
Acta Endocrinol (Copenh). 1986 Feb;111(2):271-84. doi: 10.1530/acta.0.1110271.
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Somatomedin-C/insulin-like growth factor 1-like material secreted by porcine Sertoli cells in vitro: characterization and regulation.猪支持细胞体外分泌的生长调节素C/胰岛素样生长因子1样物质：特性与调控
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Measurement of somatomedin-related peptides in fetal, neonatal, and maternal rat serum by insulin-like growth factor (IGF) I radioimmunoassay, IGF-II radioreceptor assay (RRA), and multiplication-stimulating activity RRA after acid-ethanol extraction.通过胰岛素样生长因子（IGF）I放射免疫测定法、IGF-II放射受体测定法（RRA）以及酸乙醇提取后的增殖刺激活性RRA，测定胎鼠、新生鼠和母鼠血清中生长调节素相关肽。
Endocrinology. 1982 Feb;110(2):575-81. doi: 10.1210/endo-110-2-575.
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Interaction of somatomedin-C with an antibody directed against the synthetic C-peptide region of insulin-like growth factor-I.生长调节素-C与一种针对胰岛素样生长因子-I合成C肽区域的抗体之间的相互作用。
J Clin Endocrinol Metab. 1980 Feb;50(2):405-7. doi: 10.1210/jcem-50-2-405.
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Sequence analysis of somatomedin-C: confirmation of identity with insulin-like growth factor I.生长调节素-C的序列分析：与胰岛素样生长因子I一致性的确证
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Evidence for autocrine mitogenic stimulation by somatomedin-C/insulin-like growth factor I on an established human lung cancer cell line.生长调节素-C/胰岛素样生长因子I对已建立的人肺癌细胞系的自分泌促有丝分裂刺激作用的证据。
Cancer Res. 1988 Jul 1;48(13):3716-9.
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Expression of a biologically active analogue of somatomedin-C/insulin-like growth factor I.生长调节素-C/胰岛素样生长因子I生物活性类似物的表达
Gene. 1985;35(1-2):83-9. doi: 10.1016/0378-1119(85)90160-x.
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Monoclonal antibody against human somatomedin-C/insulin-like growth factor-I.抗人生长调节素C/胰岛素样生长因子-I单克隆抗体
J Clin Endocrinol Metab. 1982 Feb;54(2):474-6. doi: 10.1210/jcem-54-2-474.

引用本文的文献

1
Somatomedin-1 (insulin-like growth factor-I) in clinical use. Facts and potential.临床应用中的生长调节素-1（胰岛素样生长因子-I）。事实与潜力。
Drugs. 1993 Jan;45(1):1-8. doi: 10.2165/00003495-199345010-00001.
2
Insulinlike growth factor I regulation of growth hormone gene transcription in primary rat pituitary cells.胰岛素样生长因子I对原代大鼠垂体细胞生长激素基因转录的调节
J Clin Invest. 1987 Feb;79(2):449-52. doi: 10.1172/JCI112832.
3
Serum insulin-like growth factor-I levels in amyotrophic lateral sclerosis.肌萎缩侧索硬化症患者的血清胰岛素样生长因子-I水平
J Neurol Neurosurg Psychiatry. 1987 Jun;50(6):792-4. doi: 10.1136/jnnp.50.6.792.
4
Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.抗I型胰岛素样生长因子（IGF-I）受体的单克隆抗体可阻断IGF-I受体介导的DNA合成：对人皮肤成纤维细胞中IGF-I和胰岛素促有丝分裂机制的阐明。
Proc Natl Acad Sci U S A. 1986 Feb;83(3):664-8. doi: 10.1073/pnas.83.3.664.
5
Presence of insulinlike growth factor receptors and lack of insulin receptors on fetal bovine smooth muscle cells.胎牛平滑肌细胞上存在胰岛素样生长因子受体且缺乏胰岛素受体。
In Vitro Cell Dev Biol. 1988 Sep;24(9):921-6. doi: 10.1007/BF02623903.