B(CF)催化的异吲哚酮的高化学选择性还原反应：吲哚-3-酮和吲哚啉的合成
B(CF)-Catalyzed Highly Chemoselective Reduction of Isatins: Synthesis of Indolin-3-ones and Indolines.
作者信息
Jeong Hyojin, Han Nara, Hwang Dong Wook, Ko Haye Min
机构信息
Department of Chemistry, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk 54538, Republic of Korea.
Wonkwang Institute of Materials Science and Technology, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk 54538, Republic of Korea.
出版信息
Org Lett. 2020 Oct 16;22(20):8150-8155. doi: 10.1021/acs.orglett.0c03150. Epub 2020 Oct 6.
A chemo- and site-selective reduction reaction of isatin derivatives using catalyst B(CF) and hydrosilanes is described. This transformation is operationally simple, proceeds under mild conditions, and is resistant to various functional groups. Thus, this efficient reaction using a combination of B(CF) and BnMeSiH or B(CF) and EtSiH could potentially be utilized to produce various indolin-3-ones and indolines, without the need for multistep procedures and metal catalysis conditions.
描述了使用催化剂B(CF)和硅烷对异吲哚酮衍生物进行化学和位点选择性还原反应。这种转化操作简单，在温和条件下进行，并且对各种官能团具有耐受性。因此，使用B(CF)和苄基甲基硅烷或B(CF)和乙基硅烷的这种有效反应有可能用于生产各种吲哚啉-3-酮和吲哚啉，而无需多步程序和金属催化条件。
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