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环状 RNA 作为子宫内膜异位症的潜在诊断和/或治疗靶点。

Circular RNA as a potential diagnostic and/or therapeutic target for endometriosis.

机构信息

Research Center for Biochemistry & Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR Iran.

Department of Gynecology & Obstetrics, Ramsar Campus, Mazandaran University of Medical Sciences, Sari, Iran.

出版信息

Biomark Med. 2020 Sep;14(13):1277-1287. doi: 10.2217/bmm-2020-0167.

Abstract

Endometriosis is a pathology form of endometrium that behaves in a similar way to malignancies, such as invasion and resistance to apoptosis. Circular RNAs (CircRNAs) are a class of noncoding RNAs that have several biological functions including, miRNA sponging, sequestering of proteins, enhancing parental gene expression and translation resulting in polypeptides. In this review, we highlighted the roles of circRNAs as potential diagnostic and therapeutic biomarkers in endometriosis. Moreover, we summarized the roles of circRNAs in the pathogenesis of endometriosis via different signaling pathways, such as the miRNA network and apoptosis.

摘要

子宫内膜异位症是一种具有类似恶性肿瘤行为的子宫内膜病理形式,如侵袭和抗细胞凋亡。环状 RNA(CircRNAs)是一类非编码 RNA,具有多种生物学功能,包括 miRNA 海绵、蛋白质隔离、增强亲本基因表达和翻译,从而产生多肽。在这篇综述中,我们强调了 circRNAs 作为子宫内膜异位症潜在诊断和治疗生物标志物的作用。此外,我们通过不同的信号通路,如 miRNA 网络和细胞凋亡,总结了 circRNAs 在子宫内膜异位症发病机制中的作用。

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