Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Front Immunol. 2023 Aug 22;14:1223828. doi: 10.3389/fimmu.2023.1223828. eCollection 2023.
Endometriosis is a complex disorder that is characterized by the abnormal growth of endometrial-like tissue outside the uterus. It is associated with chronic inflammation, severe pelvic pain, infertility, and significantly reduced quality of life. Although the exact mechanism of endometriosis remains unknown, inflammation and altered immunity are considered key factors in the immunopathogenesis of the disorder. Disturbances of immune responses result in reduced clearance of regurgitated endometrial cells, which elicits oxidative stress and progression of inflammation. Proinflammatory mediators could affect immune cells' recruitment, fate, and function. Reciprocally, the activation of immune cells can promote inflammation. Aberrant expression of non-coding RNA (ncRNA) in patient and animal lesions could be suggestive of their role in endometriosis establishment. The engagement of these RNAs in regulating diverse biological processes, including inflammatory responses and activation of inflammasomes, altered immunity, cell proliferation, migration, invasion, and angiogenesis are widespread and far-reaching. Therefore, ncRNAs can be identified as a determining candidate regulating the inflammatory responses and immune system. This review aims in addition to predict the role of ncRNAs in the immunopathogenesis of endometriosis through regulating inflammation and altered immunity based on previous studies, it presents a comprehensive view of inflammation role in the pathogenesis of endometriosis.
子宫内膜异位症是一种复杂的疾病，其特征是子宫内膜样组织在子宫外异常生长。它与慢性炎症、严重的盆腔疼痛、不孕以及生活质量显著下降有关。尽管子宫内膜异位症的确切机制尚不清楚，但炎症和免疫改变被认为是该疾病免疫发病机制的关键因素。免疫反应的紊乱导致反流的子宫内膜细胞清除减少，从而引发氧化应激和炎症的进展。促炎介质可能影响免疫细胞的募集、命运和功能。反过来，免疫细胞的激活也可以促进炎症。患者和动物病变中非编码 RNA（ncRNA）的异常表达可能表明它们在子宫内膜异位症的发生中起作用。这些 RNA 在调节多种生物过程中的广泛作用，包括炎症反应和炎症小体的激活、免疫改变、细胞增殖、迁移、侵袭和血管生成，是广泛而深远的。因此，ncRNA 可以被确定为调节炎症反应和免疫系统的决定候选物。本综述的目的除了根据以往的研究预测 ncRNA 在子宫内膜异位症免疫发病机制中的作用，通过调节炎症和免疫改变外，还介绍了炎症在子宫内膜异位症发病机制中的作用的全面观点。
