Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Jiangxi Chinese Medicine Science Center of DICP, CAS, Nanchang 330000, China.
Org Lett. 2020 Nov 6;22(21):8240-8244. doi: 10.1021/acs.orglett.0c02838. Epub 2020 Oct 6.
A pair of new macrocyclic spermidine alkaloids, (+)-()-scocycamide and (-)-()-scocycamide, were isolated from the roots of . Their structures were established by extensive spectroscopic data, electronic circular dichroism analyses, and chemical synthesis. They featured a unique 6/18 fused bicyclic framework with spermidine and catechol units, representing a new subtype of natural spermidine alkaloids. A plausible biosynthetic pathway was also proposed. They inhibited butyrylcholinesterase and exhibited antioxidant capacity, suggesting beneficial constituents against Alzheimer's disease and oxidation.
从 的根部分离得到一对新的大环 spermidine 生物碱：(+)-()-scocycamide 和 (-)-()-scocycamide。通过广泛的光谱数据分析、电子圆二色性分析和化学合成确定了它们的结构。它们具有独特的 6/18 稠合双环骨架，包含 spermidine 和儿茶酚单元，代表了天然 spermidine 生物碱的一个新亚型。还提出了一个可能的生物合成途径。它们抑制丁酰胆碱酯酶并具有抗氧化能力，提示它们是对抗阿尔茨海默病和氧化的有益成分。
