School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen 518060, China.
Molecules. 2022 Jun 17;27(12):3907. doi: 10.3390/molecules27123907.
Ferulasinkins A-D (-), four new norlignans, were isolated from the resins of , a medicinal plant of the Apiaceae family. All of them were obtained as racemic mixtures, chiral HPLC was used to produce their (+)- and (-)-antipodes. The structures of these new compounds, including their absolute configurations, were elucidated by spectroscopic and computational methods. This isolation provides new insight into the chemical profiling of resins beyond the well-investigated structure types such as sesquiterpene coumarins and disulfides. Compounds and were found to significantly inhibit the invasion and migration of triple-negative breast cancer (TNBC) cell lines via CCK-8 assay. On the other hand, the wound-healing assay also demonstrated that compounds and could promote the proliferation of human umbilical vein endothelial cells (HUVECs). Notably, the promoting effects of and were observed as more significant versus a positive control using basic fibroblast growth factor (bFGF).
从伞形科药用植物Ferula sinkiangensis 的树脂中分离得到了 4 个新的愈创木烷型木脂素 Ferulasinkins A-D(-)。它们均以外消旋混合物的形式得到，手性 HPLC 用于制备它们的 (+)-和 (-)-对映体。通过光谱和计算方法阐明了这些新化合物的结构，包括它们的绝对构型。这种分离为除了已充分研究的结构类型（如倍半萜香豆素和二硫化物）之外的 Ferula sinkiangensis 树脂的化学分析提供了新的见解。通过 CCK-8 测定法发现化合物和显著抑制三阴性乳腺癌（TNBC）细胞系的侵袭和迁移。另一方面，划痕愈合试验也表明化合物和可以促进人脐静脉内皮细胞（HUVEC）的增殖。值得注意的是，与碱性成纤维细胞生长因子（bFGF）的阳性对照相比，观察到化合物和的促进作用更为显著。
