Racemic Norlignans as Diastereoisomers from Resins with Antitumor and Wound-Healing Promotion Activities.

Ferulasinkins A-D (-), four new norlignans, were isolated from the resins of , a medicinal plant of the Apiaceae family. All of them were obtained as racemic mixtures, chiral HPLC was used to produce their (+)- and (-)-antipodes. The structures of these new compounds, including their absolute configurations, were elucidated by spectroscopic and computational methods. This isolation provides new insight into the chemical profiling of resins beyond the well-investigated structure types such as sesquiterpene coumarins and disulfides. Compounds and were found to significantly inhibit the invasion and migration of triple-negative breast cancer (TNBC) cell lines via CCK-8 assay. On the other hand, the wound-healing assay also demonstrated that compounds and could promote the proliferation of human umbilical vein endothelial cells (HUVECs). Notably, the promoting effects of and were observed as more significant versus a positive control using basic fibroblast growth factor (bFGF).