Krummel T M, Nelson J M, Diegelmann R F, Lindblad W J, Salzberg A M, Greenfield L J, Cohen I K
J Pediatr Surg. 1987 Jul;22(7):640-4. doi: 10.1016/s0022-3468(87)80117-3.
Fetal, neonatal, and adult tissue response to a standardized injury was studied using subcutaneous wound implants, linear incisions, and punch wounds in New Zealand white rabbits. In the fetus, sutured incisions healed by primary intention without antecedent inflammation. However, neither contraction nor healing by secondary intention was seen in punch or unsutured wounds. Healing both by primary and secondary intention following inflammatory infiltration was observed uniformly in neonatal and adult rabbits. Wound implants were extensively infiltrated with collagen in the adults studied; however, no collagen was seen in fetal implants and collagen hydroxyproline content could not even be detected by high performance liquid chromatography techniques; rather, a matrix rich in hyaluronic acid was found. The fetal tissue response to injury differs from the adult, proceeding in the absence of a classical inflammatory stimulus and lacking contractile capabilities. The deposition of extracellular matrix rich in hyaluronic acid but devoid of collagen suggests that the fetal response to injury may be a process more closely resembling regeneration or growth rather than repair by scar deposition.
利用皮下伤口植入物、线性切口和打孔伤口，在新西兰白兔身上研究了胎儿、新生儿和成年组织对标准化损伤的反应。在胎儿中，缝合切口一期愈合，无前期炎症。然而，在打孔伤口或未缝合伤口中，未见收缩或二期愈合。在新生兔和成年兔中均观察到炎症浸润后一期和二期愈合。在所研究的成年兔中，伤口植入物被大量胶原蛋白浸润；然而，在胎儿植入物中未见胶原蛋白，甚至用高效液相色谱技术也检测不到胶原蛋白羟脯氨酸含量；相反，发现了富含透明质酸的基质。胎儿组织对损伤的反应不同于成年组织，在没有经典炎症刺激的情况下进行，且缺乏收缩能力。富含透明质酸但不含胶原蛋白的细胞外基质的沉积表明，胎儿对损伤的反应可能是一个更类似于再生或生长而非瘢痕沉积修复的过程。
